Blood Plasma Small Non-Coding RNAs as Diagnostic Molecules for the Progesterone-Receptor-Negative Phenotype of Serous Ovarian Tumors

• Published in: International journal of molecular sciences Vol. 24; no. 15; p. 12214
• Main Authors: Timofeeva, Angelika V, Fedorov, Ivan S, Asaturova, Aleksandra V, Sannikova, Maya V, Tregubova, Anna V, Mayboroda, Oleg A, Khabas, Grigory N, Frankevich, Vladimir E, Sukhikh, Gennady T
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.07.2023; MDPI
• Subjects: Adjuvant treatment; Analysis; Biomarkers; Biosynthesis; CA125; Cancer; Cancer therapies; Chemotherapy; Development and progression; Disease; DNA methylation; Gene expression; Genetic aspects; Medical screening; MicroRNA; MicroRNAs; miRNA; Mortality; mRNA; Mucins; new-generation sequencing (NGS); Ovarian cancer; piRNA; Progesterone; progesterone receptor (PGR); Tumors; Germany; Russia; borderline cystadenoma; cytoreduction; mRNA; blood plasma; formalin-fixed paraffin-embedded (FFPE) blocks; new-generation sequencing (NGS); piRNA; quantitative RT-PCR; CA125; miRNA; serous ovarian carcinoma; benign cystadenoma; progesterone receptor (PGR)

The expression level of the progesterone receptor (PGR) plays a crucial role in determining the biological characteristics of serous ovarian carcinoma. Low PGR expression is associated with chemoresistance and a poorer outcome. In this study, our objective was to explore the relationship between tum...