Cerebellar Transcriptomic Analysis in a Chronic plus Binge Mouse Model of Alcohol Use Disorder Demonstrates Ethanol-Induced Neuroinflammation and Altered Glial Gene Expression

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 5; p. 745
• Main Authors: Holloway, Kalee N, Pinson, Marisa R, Douglas, James C, Rafferty, Tonya M, Kane, Cynthia J M, Miranda, Rajesh C, Drew, Paul D
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.02.2023; MDPI
• Subjects: Alcohol use; Alcoholism; Alcoholism - pathology; Animals; astrocyte; AUD; Cerebellum; Cerebellum - metabolism; Chronic Disease; Ethanol; Ethanol - metabolism; Gene expression; Genetic aspects; Health aspects; Homeostasis; Immune response; Immune response (cell-mediated); Inflammation; Laboratory animals; Mice; Mice, Inbred C57BL; microglia; Neurodegeneration; Neurodegenerative diseases; Neuroglia; neuroinflammation; Neuroinflammatory Diseases; Neuronal-glial interactions; Next-generation sequencing; oligodendrocyte; Oligodendrocytes; RNA; RNA - metabolism; Software; Transcriptome; Transcriptomics; United States; United States > US; AUD; transcriptomics; neuroinflammation; astrocyte; microglia; oligodendrocyte

Alcohol use disorder (AUD) is one of the most common preventable mental health disorders and can result in pathology within the CNS, including the cerebellum. Cerebellar alcohol exposure during adulthood has been associated with disruptions in proper cerebellar function. However, the mechanisms regu...