Follow-up of plasma semicarbazide-sensitive amine oxidase activity and retinopathy in Type 2 diabetes mellitus

• Published in: Journal of diabetes and its complications Vol. 15; no. 5; pp. 250 - 256
• Main Authors: Grönvall-Nordquist, Jenny L.E., Bäcklund, Lars B., Garpenstrand, Håkan, Ekblom, Jonas, Landin, Britta, Yu, Peter H., Oreland, Lars, Rosenqvist, Urban
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.09.2001; Elsevier Science
• Subjects: Aged; Amine Oxidase (Copper-Containing) - blood; Associated diseases and complications; Benzylamine; Biological and medical sciences; Creatinine - blood; Creatinine - urine; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic Retinopathy - blood; Diabetic Retinopathy - pathology; Diabetic Retinopathy - urine; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Follow-Up Studies; Fundus Oculi; Glycated Hemoglobin A - analysis; Hemoglobin A glycosylated; Humans; Male; Medical sciences; Methylamine; Methylamines - urine; Middle Aged; Photography; Vascular adhesion protein-1; Hemoglobin A glycosylated; Methylamine; Vascular adhesion protein-1; Benzylamine; Endocrinopathy; Human; Urine; Prognosis; Retinopathy; Enzyme; Diabetes mellitus; Amine oxidase (copper-containing); Ion exchange chromatography; Blood plasma; Eye disease; Enzymatic activity; Surveillance; Oxidoreductases

Plasma activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO) is high in diabetes. Production of angiotoxic substances (an aldehyde, hydrogen peroxide, and ammonia) in vessel walls is catalysed by SSAO, suggesting a role for SSAO in the development of complications of diabetes. The obje...