Perioperative Statin Therapy for Patients Undergoing Coronary Artery Bypass Grafting

• Published in: The Annals of thoracic surgery Vol. 101; no. 2; pp. 818 - 825
• Main Authors: Barakat, Amr F., MD, Saad, Marwan, MD, PhD, Abuzaid, Ahmed, MD, Mentias, Amgad, MD, Mahmoud, Ahmed, MD, Elgendy, Islam Y., MD
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.02.2016
• Subjects: Cardiothoracic Surgery; Coronary Artery Bypass; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Perioperative Care; Postoperative Complications - prevention & control; Surgery; renal replacement therapy; OR; AF; CI; odds ratio; randomized controlled trials; low-density lipoprotein; PST; atrial fibrillation; preoperative statin therapy; systemic inflammatory response; LDL; RRT; RCTs; acute kidney injury; confidence interval; CABG; SIR; AKI; coronary artery bypass grafting

Coronary artery bypass grafting is associated with an intense systemic inflammatory response, which is linked to postoperative complications. Beyond lipid lowering, statins exert a constellation of beneficial actions, including an antiinflammatory role, known as pleiotropic effects. There is increas...