Viral protein R inhibitors from Swertia chirata of Myanmar

• Published in: Journal of bioscience and bioengineering Vol. 128; no. 4; pp. 445 - 449
• Main Authors: Woo, So-Yeun, Win, Nwet Nwet, Noe Oo, Wyine Myat, Ngwe, Hla, Ito, Takuya, Abe, Ikuro, Morita, Hiroyuki
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 01.10.2019
• Subjects: Bellidifolin; chloroform; diterpenoids; fumagillin; glycosides; HIV infections; human cell lines; Human immunodeficiency virus 1; Human immunodeficiency virus 2; iridoids; Myanmar; Oleanolic acid; plasmids; quercetin; secondary metabolites; seeds; Simian immunodeficiency virus; Swertia chirata; Swertia chirayita; synthetic biology; therapeutics; TREx-HeLa-Vpr cells; Vpr inhibitors; xanthone; Xanthone derivatives; Myanmar; Swertia chirata; TREx-HeLa-Vpr cells; Vpr inhibitors; Xanthone derivatives; Bellidifolin; Oleanolic acid

Viral protein R (Vpr) is a small, basic accessory protein (14 kDa) that is well conserved in Human immunodeficiency virus-1 (HIV-1), HIV-2, and simian immunodeficiency virus (SIV). Numerous investigations over the past 2 decades have suggested that Vpr would be an attractive target for HIV disease t...