Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes

• Published in: International journal of molecular sciences Vol. 24; no. 13; p. 10941
• Main Authors: Tran, Michelle, Yang, Kevin, Glukhova, Alisa, Holinstat, Michael, Holman, Theodore
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.06.2023; MDPI
• Subjects: Acyl Coenzyme A - metabolism; acyl-coenzyme A; Allosteric properties; Arachidonate 12-lipoxygenase; Coenzyme A; Enzymes; Ethylenediaminetetraacetic acid; Fatty acids; Humans; Inflammation; inhibition; Investigations; Isoenzymes; Linoleic acid; Lipid metabolism; Lipids; Lipoxygenase; Liquid oxygen; LOX-1 protein; Metabolism; Oxylipins; Physiological aspects; Resveratrol; Reticulocytes; Scavenger Receptors, Class E; Substrate inhibition; Type 2 diabetes; Australia; acyl-coenzyme A; lipoxygenase; inhibition

Lipid metabolism is a complex process crucial for energy production resulting in high levels of acyl-coenzyme A (acyl-CoA) molecules in the cell. Acyl-CoAs have also been implicated in inflammation, which could be possibly linked to lipoxygenase (LOX) biochemistry by the observation that an acyl-CoA...