An Insight into Survivin in Relevance to Hematological, Biochemical and Genetic Characteristics in Tobacco Chewers with Oral Squamous Cell Carcinoma

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 10; p. 1444
• Main Authors: Yesupatham, Susanna Theophilus, Dayanand, C. D., Azeem Mohiyuddin, S. M., Harendra Kumar, M. L.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2023; MDPI
• Subjects: Adult; Aged; Angiogenesis; Apoptosis; Bioinformatics; Biomarkers; BIRC5; Blood; Cancer therapies; Carcinogens; Cell cycle; Cheek; Chemotherapy; Chromosome 17; Cyclin-dependent kinases; Cytokines; Deoxyribonucleic acid; DNA; Exons; Female; Genes; Genetic analysis; Genetic aspects; Health aspects; Hematology; Humans; IAP protein; Inflammation; Kinases; Leukocyte Count; Leukocytes (neutrophilic); LMR; Lung cancer; Lymphocytes; Male; Measurement; Metastasis; Middle Aged; Monocytes; Mouth cancer; Mouth Neoplasms - blood; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Mutation; Nicotine; NLR; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; OSCC; Ovarian cancer; Physiological aspects; PLR; Polymorphism; Promoter Regions, Genetic; Proteins; Sequence analysis; Signal transduction; Squamous Cell Carcinoma of Head and Neck - blood; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - metabolism; Survivin; Survivin - genetics; Survivin - metabolism; Tobacco; Tobacco chewing; Tobacco Use - genetics; Tobacco Use - metabolism; Tobacco, Smokeless - adverse effects; Tumors; India; Southeast Asia; LMR; OSCC; survivin; nicotine; NLR; PLR; BIRC5

Background: Survivin is an inhibitor of apoptosis protein (IAP), encoded by the Baculoviral IAP Repeat Containing 5 (BIRC5) gene located on q arm (25.3) on chromosome 17. It is expressed in various human cancers and involved in tumor resistance to radiation and chemotherapy. The genetic analysis of...