Effect of folpet on hypoglycaemia, intestinal microbiota, and drug resistance genes in mice

• Published in: BMC microbiology Vol. 25; no. 1; pp. 11 - 9
• Main Authors: Cao, Tingting, Guo, Yajie, Lin, Liangqiang, Wang, Dan, Liu, Zhiyang, Zou, Xuan, Ke, Yuebin, Lv, Ziquan
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.01.2025; BioMed Central; BMC
• Subjects: Abundance; Airborne microorganisms; Animals; Antibiotics; Bacteria - classification; Bacteria - drug effects; Bacteria - genetics; Bacteria - isolation & purification; Blood; Blood glucose; Blood Glucose - drug effects; Blood Glucose - metabolism; Blood levels; Body weight; Chronic illnesses; Correlation analysis; Development and progression; Digestive system; Drug dosages; Drug metabolism; Drug resistance; Folpet; Fungicides; Gastrointestinal Microbiome - drug effects; Gastrointestinal Microbiome - genetics; Gastrointestinal tract; Gene expression; Gene regulation; Gene sequencing; Genes; Genetic aspects; Glucose; Glucose metabolism; Health aspects; Homeostasis; Hypoglycemia; Hypoglycemia - chemically induced; Hypoglycemia - genetics; In vivo methods and tests; Intestinal microbiota; Intestinal microflora; Laboratory animals; Male; Metabolism; Metabolome; Metabolomics; Metagenomics; Mice; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Mildew; Oral administration; Pesticides; Pharmacology, Experimental; Physiological aspects; Plant protection; Resistance genes; Risk factors; Software; Sulfonamides; Sulfonamides - pharmacology; China; Tianjin China; Beijing China; United States > US; Metabolome; Resistance genes; Intestinal microbiota; Folpet

Folpet is a nonspecific sulfonamide fungicide widely used to protect crops from mildew. However, the in vivo effects of folpet on glucose metabolism homeostasis, gut microbiota, and abundance of drug resistance genes remain unknown. The purpose of this study was to assess the effects of the pesticid...