Association between methylation of the glucocorticoid receptor gene, childhood maltreatment, and clinical severity in borderline personality disorder

• Published in: Journal of psychiatric research Vol. 57; pp. 34 - 40
• Main Authors: Martín-Blanco, Ana, Ferrer, Marc, Soler, Joaquim, Salazar, Juliana, Vega, Daniel, Andión, Oscar, Sanchez-Mora, Cristina, Arranz, Maria Jesús, Ribases, Marta, Feliu-Soler, Albert, Pérez, Víctor, Pascual, Juan Carlos
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.10.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Biological and medical sciences; Borderline personality disorder; Borderline Personality Disorder - genetics; Borderline Personality Disorder - psychology; Child; Child Abuse - psychology; Childhood trauma; DNA Methylation - genetics; Epigenetics; Female; Gene-Environment Interaction; Genetics; Glucocorticoid receptor gene; Hospitalization; Humans; Male; Medical sciences; Methylation; Personality disorders; Promoter Regions, Genetic - genetics; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Glucocorticoid - genetics; Self-Injurious Behavior - genetics; Severity of Illness Index; Victimology; Young Adult; Glucocorticoid receptor gene; Epigenetics; Genetics; Methylation; Childhood trauma; Borderline personality disorder; Borderline; Victimology; Genetic determinism; Personality disorder; Child abuse; Gene; Glucocorticoid receptor; Early traumatism; Epigenesis; Severity score
• ISSN: 0022-3956; 1879-1379; 1879-1379
• DOI: 10.1016/j.jpsychires.2014.06.011

The hypothalamus-pituitary-adrenal axis (HPA) is essential in the regulation of stress responses. Increased methylation of the promoter region of the glucocorticoid receptor gene (NR3C1) has been described both in subjects with history of childhood trauma and in patients with Borderline Personality...