Triglyceride-Glucose Index Predicts Major Adverse Cardiovascular and Cerebrovascular Events in Non-Diabetic Individuals
The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established. To investigate the potential of the TyG index to predict MACCEs in a non-diabetic popu...
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| Published in | Balkan medical journal Vol. 42; no. 4; pp. 339 - 346 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Turkey
Galenos Yayinevi Tic. Ltd
01.07.2025
Aves Yayincilik Ltd. STI Galenos Publishing Galenos Publishing House |
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| Abstract | The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established.
To investigate the potential of the TyG index to predict MACCEs in a non-diabetic population.
Prospective cohort study.
This study analyzed data from 88,946 participants without diabetes, who were divided into four groups based on their TyG index values. The primary outcome was the occurrence of MACCEs, defined as myocardial infarction (MI) or stroke. Multivariable Cox proportional hazards regression models were used to assess the association between the TyG index and MACCEs.
Participants in the higher TyG index quartiles exhibited a greater risk of MACCEs. Moreover, a significant interaction between the TyG index and sex was identified, with a stronger association observed in women than in men. A significant interaction was also found between the TyG index and age in relation to MI risk, indicating a stronger associations in individuals younger than 60 compared to those aged 60 or older.
The TyG index may serve as a useful prognostic marker for MACCEs among individuals without diabetes. |
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| AbstractList | The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established.
To investigate the potential of the TyG index to predict MACCEs in a non-diabetic population.
Prospective cohort study.
This study analyzed data from 88,946 participants without diabetes, who were divided into four groups based on their TyG index values. The primary outcome was the occurrence of MACCEs, defined as myocardial infarction (MI) or stroke. Multivariable Cox proportional hazards regression models were used to assess the association between the TyG index and MACCEs.
Participants in the higher TyG index quartiles exhibited a greater risk of MACCEs. Moreover, a significant interaction between the TyG index and sex was identified, with a stronger association observed in women than in men. A significant interaction was also found between the TyG index and age in relation to MI risk, indicating a stronger associations in individuals younger than 60 compared to those aged 60 or older.
The TyG index may serve as a useful prognostic marker for MACCEs among individuals without diabetes. Background: The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established. Aims: To investigate the potential of the TyG index to predict MACCEs in a non-diabetic population. Study Design: Prospective cohort study. Methods: This study analyzed data from 88,946 participants without diabetes, who were divided into four groups based on their TyG index values. The primary outcome was the occurrence of MACCEs, defined as myocardial infarction (MI) or stroke. Multivariable Cox proportional hazards regression models were used to assess the association between the TyG index and MACCEs. Results: Participants in the higher TyG index quartiles exhibited a greater risk of MACCEs. Moreover, a significant interaction between the TyG index and sex was identified, with a stronger association observed in women than in men. A significant interaction was also found between the TyG index and age in relation to MI risk, indicating a stronger associations in individuals younger than 60 compared to those aged 60 or older. Conclusion: The TyG index may serve as a useful prognostic marker for MACCEs among individuals without diabetes. The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established.BackgroundThe association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in individuals without diabetes has not been clearly established.To investigate the potential of the TyG index to predict MACCEs in a non-diabetic population.AimsTo investigate the potential of the TyG index to predict MACCEs in a non-diabetic population.Prospective cohort study.Study DesignProspective cohort study.This study analyzed data from 88,946 participants without diabetes, who were divided into four groups based on their TyG index values. The primary outcome was the occurrence of MACCEs, defined as myocardial infarction (MI) or stroke. Multivariable Cox proportional hazards regression models were used to assess the association between the TyG index and MACCEs.MethodsThis study analyzed data from 88,946 participants without diabetes, who were divided into four groups based on their TyG index values. The primary outcome was the occurrence of MACCEs, defined as myocardial infarction (MI) or stroke. Multivariable Cox proportional hazards regression models were used to assess the association between the TyG index and MACCEs.Participants in the higher TyG index quartiles exhibited a greater risk of MACCEs. Moreover, a significant interaction between the TyG index and sex was identified, with a stronger association observed in women than in men. A significant interaction was also found between the TyG index and age in relation to MI risk, indicating a stronger associations in individuals younger than 60 compared to those aged 60 or older.ResultsParticipants in the higher TyG index quartiles exhibited a greater risk of MACCEs. Moreover, a significant interaction between the TyG index and sex was identified, with a stronger association observed in women than in men. A significant interaction was also found between the TyG index and age in relation to MI risk, indicating a stronger associations in individuals younger than 60 compared to those aged 60 or older.The TyG index may serve as a useful prognostic marker for MACCEs among individuals without diabetes.ConclusionThe TyG index may serve as a useful prognostic marker for MACCEs among individuals without diabetes. |
| Audience | Academic |
| Author | Qi, Qi Li, Cangtuo Deng, Jie Wu, Shouling Han, Quanle Li, Wansong Zhang, Xuechao Li, Lei Li, Kangbo |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40459442$$D View this record in MEDLINE/PubMed |
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| Snippet | The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs) in... Background: The association between the triglyceride-glucose (TyG) index and the occurrence of major adverse cardiovascular and cerebrovascular events (MACCEs)... |
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| SubjectTerms | Acute coronary syndromes Adult Aged Analysis Biomarkers - analysis Biomarkers - blood Blood Glucose - analysis Cardiovascular diseases Cardiovascular Diseases - blood Cerebrovascular disease Cerebrovascular Disorders Cohort Studies Dextrose Diabetes Female Glucose Health aspects Heart attack Humans Insulin Laboratories Male Middle Aged Mortality Original Prognosis Proportional Hazards Models Prospective Studies Risk Factors Stroke Triglycerides Triglycerides - analysis Triglycerides - blood Type 2 diabetes Variables |
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| Title | Triglyceride-Glucose Index Predicts Major Adverse Cardiovascular and Cerebrovascular Events in Non-Diabetic Individuals |
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