Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 30; no. 1; pp. 274 - 15
• Main Authors: Lu, Yuanhua, Li, Hui, Zhao, Peiyan, Wang, Xinyue, Shao, Wenjun, Liu, Yan, Tian, Lin, Zhong, Rui, Liu, Haifeng, Cheng, Ying
• Format: Journal Article
• Language: English
• Published: England BioMed Central 25.12.2024; BMC
• Subjects: Antibodies; Antigen presentation; Antigens; Bioinformatics; CAF; Cancer-Associated Fibroblasts - metabolism; Cell Communication; Cell Line, Tumor; Cells; Chemotherapy; Coculture Techniques; Colorectal cancer; Computational Biology - methods; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes; Genomics; Genotype & phenotype; Glucose; Glycolysis; Humans; Lung cancer; Lung Neoplasms - genetics; Lung Neoplasms - immunology; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lymphocytes; Metabolism; Metabolites; Metastasis; Polyesters; Reagents; SCLC; Signal Transduction; Small Cell Lung Carcinoma - genetics; Small Cell Lung Carcinoma - metabolism; Small Cell Lung Carcinoma - pathology; STING signaling; Transcription factors; Transcriptome; Tumor Microenvironment; Beijing China; United States > US; China; Glycolysis; Antigen presentation; SCLC; CAF; STING signaling

Small cell lung cancer (SCLC) is a highly fatal malignancy, the complex tumor microenvironment (TME) is a critical factor affecting SCLC progression. Cancer-associated fibroblasts (CAFs) are crucial components of TME, yet their role in SCLC and the underlying mechanisms during their interaction with...