Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function

• Published in: Kidney international Vol. 79; no. 10; pp. 1119 - 1130
• Main Authors: Endre, Zoltán H., Pickering, John W., Walker, Robert J., Devarajan, Prasad, Edelstein, Charles L., Bonventre, Joseph V., Frampton, Christopher M., Bennett, Michael R., Ma, Qing, Sabbisetti, Venkata S., Vaidya, Vishal S., Walcher, Angela M., Shaw, Geoffrey M., Henderson, Seton J., Nejat, Maryam, Schollum, John B.W., George, Peter M.
• Format: Journal Article
• Language: English
• Published: Basingstoke Elsevier Inc 01.05.2011; Nature Publishing Group; Elsevier Limited
• Subjects: acute kidney injury; Acute Kidney Injury - diagnosis; Acute Kidney Injury - physiopathology; Acute Kidney Injury - urine; Acute-Phase Proteins - urine; Adult; Aged; Area Under Curve; Biological and medical sciences; Biomarkers - urine; clinical trail; Critical Illness; diagnosis; Female; gamma-Glutamyltransferase - urine; Glomerular Filtration Rate; Humans; Interleukin-18 - urine; Kidneys; Lipocalin-2; Lipocalins - urine; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Proto-Oncogene Proteins - urine; Renal Dialysis; Time Factors; Urinary system involvement in other diseases. Miscellaneous; clinical trail; diagnosis; acute kidney injury; glomerular filtration rate; Kidney disease; Performance evaluation; Human; Urine; Nephrology; Urinary system disease; Renal function; Critically ill; Acute kidney injury; Biological marker; Biological indicator; Duration; Urology; Glomerular filtration rate; Diagnosis

To better understand the diagnostic and predictive performance of urinary biomarkers of kidney injury, we evaluated γ-glutamyltranspeptidase (GGT), alkaline phosphatase (AP), neutrophil-gelatinase-associated lipocalin (NGAL), cystatin C (CysC), kidney injury molecule-1 (KIM-1), and interleukin-18 (I...