RNF20 and histone H2B ubiquitylation exert opposing effects in Basal-Like versus luminal breast cancer

• Published in: Cell death and differentiation Vol. 24; no. 4; pp. 694 - 704
• Main Authors: Tarcic, Ohad, Granit, Roy Z, Pateras, Ioannis S, Masury, Hadas, Maly, Bella, Zwang, Yaara, Yarden, Yosef, Gorgoulis, Vassilis G, Pikarsky, Eli, Ben-Porath, Ittai, Oren, Moshe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2017; Nature Publishing Group
• Subjects: 13/1; 13/89; 631/67/395; 631/67/68; 64/60; Animals; Apoptosis; Biochemistry; Biology; Biomedical and Life Sciences; Breast cancer; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cancer research; Cell Biology; Cell Cycle Analysis; Cell death; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal cancer; Cytokines; Cytokines - metabolism; Estrogens; Female; Histones - metabolism; Humans; Inflammatory bowel disease; Interleukin-6 - genetics; Interleukin-6 - metabolism; Life Sciences; MCF-7 Cells; Medical research; Metastasis; Mice; NF-kappa B - metabolism; Original Paper; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Stem Cells; Survival Rate; Transcription Factor RelA - antagonists & inhibitors; Transcription Factor RelA - genetics; Transcription Factor RelA - metabolism; Tumorigenesis; Tumors; Ubiquitin Thiolesterase; Ubiquitin-Protein Ligases - antagonists & inhibitors; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitin-Specific Proteases - antagonists & inhibitors; Ubiquitin-Specific Proteases - genetics; Ubiquitin-Specific Proteases - metabolism; Ubiquitination; Greece; Athens Greece; Israel; Jerusalem Israel

Breast cancer subtypes display distinct biological traits that influence their clinical behavior and response to therapy. Recent studies have highlighted the importance of chromatin structure regulators in tumorigenesis. The RNF20-RNF40 E3 ubiquitin ligase complex monoubiquitylates histone H2B to ge...