Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 6; p. 971
• Main Authors: Du, Hongmei, Huo, Zijun, Chen, Yanchun, Zhao, Zhenhan, Meng, Fandi, Wang, Xuemei, Liu, Shiyue, Zhang, Haoyun, Zhou, Fenghua, Liu, Jinmeng, Zhang, Lingyun, Zhou, Shuanhu, Guan, Yingjun, Wang, Xin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2023; MDPI
• Subjects: Amyotrophic lateral sclerosis; Amyotrophic Lateral Sclerosis - genetics; Amyotrophic Lateral Sclerosis - metabolism; Amyotrophic Lateral Sclerosis - therapy; Animals; Care and treatment; Cell differentiation; Cell lines; Cell therapy; Cell- and Tissue-Based Therapy; Cellular therapy; Central nervous system; Development and progression; Disease; disease modeling; Drug screening; Efficiency; Family medical history; Fibroblasts; Genotypes; Glial cells; Health aspects; induced pluripotent stem cells; Induced Pluripotent Stem Cells - metabolism; Inhibitory postsynaptic potentials; Methods; Mutation; Nervous system; Neurodegenerative diseases; Neurodegenerative Diseases - metabolism; Neuronal-glial interactions; Neurons - metabolism; Oxidative stress; Pathogenesis; Phenotypes; Physiological aspects; Pluripotency; Proteins; Review; Somatic cells; Stem cells; China; induced pluripotent stem cells; drug screening; amyotrophic lateral sclerosis; cell therapy; disease modeling

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Mo...