Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Mo...

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Published inCells (Basel, Switzerland) Vol. 12; no. 6; p. 971
Main Authors Du, Hongmei, Huo, Zijun, Chen, Yanchun, Zhao, Zhenhan, Meng, Fandi, Wang, Xuemei, Liu, Shiyue, Zhang, Haoyun, Zhou, Fenghua, Liu, Jinmeng, Zhang, Lingyun, Zhou, Shuanhu, Guan, Yingjun, Wang, Xin
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2023
MDPI
Subjects
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - therapy
Animals
Care and treatment
Cell differentiation
Cell lines
Cell therapy
Cell- and Tissue-Based Therapy
Cellular therapy
Central nervous system
Development and progression
Disease
disease modeling
Drug screening
Efficiency
Family medical history
Fibroblasts
Genotypes
Glial cells
Health aspects
induced pluripotent stem cells
Induced Pluripotent Stem Cells - metabolism
Inhibitory postsynaptic potentials
Methods
Mutation
Nervous system
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neuronal-glial interactions
Neurons - metabolism
Oxidative stress
Pathogenesis
Phenotypes
Physiological aspects
Pluripotency
Proteins
Review
Somatic cells
Stem cells
China
induced pluripotent stem cells
drug screening
amyotrophic lateral sclerosis
cell therapy
disease modeling
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Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Most studies have applied animal or single-gene intervention cell lines as ALS disease models, but they cannot accurately reflect the pathological characteristics of ALS. Induced pluripotent stem cells (iPSCs) can be reprogrammed from somatic cells, possessing the ability to self-renew and differentiate into a variety of cells. iPSCs can be obtained from ALS patients with different genotypes and phenotypes, and the genetic background of the donor cells remains unchanged during reprogramming. iPSCs can differentiate into neurons and glial cells related to ALS. Therefore, iPSCs provide an excellent method to evaluate the impact of diseases on ALS patients. Moreover, patient-derived iPSCs are obtained from their own somatic cells, avoiding ethical concerns and posing only a low risk of immune rejection. The iPSC technology creates new hope for ALS treatment. Here, we review recent studies on iPSCs and their applications in disease modeling, drug screening and cell therapy in ALS, with a particular focus on the potential for ALS treatment.
AbstractList Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Most studies have applied animal or single-gene intervention cell lines as ALS disease models, but they cannot accurately reflect the pathological characteristics of ALS. Induced pluripotent stem cells (iPSCs) can be reprogrammed from somatic cells, possessing the ability to self-renew and differentiate into a variety of cells. iPSCs can be obtained from ALS patients with different genotypes and phenotypes, and the genetic background of the donor cells remains unchanged during reprogramming. iPSCs can differentiate into neurons and glial cells related to ALS. Therefore, iPSCs provide an excellent method to evaluate the impact of diseases on ALS patients. Moreover, patient-derived iPSCs are obtained from their own somatic cells, avoiding ethical concerns and posing only a low risk of immune rejection. The iPSC technology creates new hope for ALS treatment. Here, we review recent studies on iPSCs and their applications in disease modeling, drug screening and cell therapy in ALS, with a particular focus on the potential for ALS treatment.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Most studies have applied animal or single-gene intervention cell lines as ALS disease models, but they cannot accurately reflect the pathological characteristics of ALS. Induced pluripotent stem cells (iPSCs) can be reprogrammed from somatic cells, possessing the ability to self-renew and differentiate into a variety of cells. iPSCs can be obtained from ALS patients with different genotypes and phenotypes, and the genetic background of the donor cells remains unchanged during reprogramming. iPSCs can differentiate into neurons and glial cells related to ALS. Therefore, iPSCs provide an excellent method to evaluate the impact of diseases on ALS patients. Moreover, patient-derived iPSCs are obtained from their own somatic cells, avoiding ethical concerns and posing only a low risk of immune rejection. The iPSC technology creates new hope for ALS treatment. Here, we review recent studies on iPSCs and their applications in disease modeling, drug screening and cell therapy in ALS, with a particular focus on the potential for ALS treatment.Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS) and ultimately death. The mechanisms underlying ALS pathogenesis have not yet been fully elucidated, and ALS cannot be treated effectively. Most studies have applied animal or single-gene intervention cell lines as ALS disease models, but they cannot accurately reflect the pathological characteristics of ALS. Induced pluripotent stem cells (iPSCs) can be reprogrammed from somatic cells, possessing the ability to self-renew and differentiate into a variety of cells. iPSCs can be obtained from ALS patients with different genotypes and phenotypes, and the genetic background of the donor cells remains unchanged during reprogramming. iPSCs can differentiate into neurons and glial cells related to ALS. Therefore, iPSCs provide an excellent method to evaluate the impact of diseases on ALS patients. Moreover, patient-derived iPSCs are obtained from their own somatic cells, avoiding ethical concerns and posing only a low risk of immune rejection. The iPSC technology creates new hope for ALS treatment. Here, we review recent studies on iPSCs and their applications in disease modeling, drug screening and cell therapy in ALS, with a particular focus on the potential for ALS treatment.
Audience Academic
Author Zhao, Zhenhan
Zhang, Haoyun
Wang, Xuemei
Wang, Xin
Zhou, Shuanhu
Meng, Fandi
Liu, Jinmeng
Du, Hongmei
Liu, Shiyue
Chen, Yanchun
Guan, Yingjun
Huo, Zijun
Zhou, Fenghua
Zhang, Lingyun
AuthorAffiliation 5 Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
3 Department of Pathology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, China
4 Harvard Medical School and Harvard Stem Cell Institute, Harvard University, Boston, MA 02115, USA; shuanhuzhou@gmail.com
1 Department of Histology and Embryology, School of Basic Medical Sciences, Weifang Medical University, Weifang 261053, China; hongmeiduwf@163.com (H.D.); zijunhuo1998@163.com (Z.H.); cyc7907@wfmc.edu.cn (Y.C.); jinqiuhupan@163.com (Z.Z.); 18800460605@163.com (F.M.); 18863662168@163.com (X.W.)
2 Neurologic Disorders and Regenerative Repair Laboratory, Weifang Medical University, Weifang 261053, China; liu08308399@163.com (S.L.); haoyunzh@163.com (H.Z.); zhoufh@wfmc.edu.cn (F.Z.); 18353687185@163.com (J.L.); zly199311@126.com (L.Z.)
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Cites_doi 10.1007/s00401-013-1149-y
10.3389/fncel.2015.00289
10.5966/sctm.2012-0042
10.3390/biomedicines9070753
10.1001/jamaneurol.2020.4300
10.1111/jnc.15289
10.1038/362059a0
10.1093/hmg/ddw163
10.1016/j.stem.2009.08.021
10.1016/j.neuron.2008.10.013
10.1038/s41593-021-01006-0
10.1523/JNEUROSCI.2126-14.2015
10.1002/acn3.51078
10.1016/j.celrep.2014.03.019
10.1016/j.stem.2014.02.004
10.1016/j.stemcr.2022.01.004
10.3389/fddsv.2021.773424
10.1016/j.neuron.2019.05.048
10.1002/glia.23761
10.1038/s41419-020-03102-8
10.1016/j.ymeth.2021.09.002
10.1080/21678421.2020.1828475
10.1007/s10048-015-0448-y
10.1016/S0140-6736(22)01272-7
10.3109/00207454.2015.1096271
10.1002/ana.26047
10.3390/antiox7020025
10.1016/j.chest.2018.06.035
10.1016/j.stemcr.2021.10.010
10.1007/s00401-005-1019-3
10.1186/s40478-018-0564-7
10.1038/nm.4189
10.15252/embj.2018101033
10.1016/j.isci.2021.103221
10.1136/jnnp-2016-315018
10.2174/187152710793237502
10.1016/j.jbiosc.2021.06.015
10.1093/nar/gkab582
10.1016/j.scr.2019.101448
10.1016/j.stem.2009.05.005
10.1093/hmg/ddt425
10.1038/s41591-018-0140-5
10.1111/ene.14393
10.1016/j.scr.2022.102788
10.1101/2021.12.30.474573
10.1002/ana.410390519
10.1016/j.gene.2015.11.049
10.1038/s41467-017-00911-y
10.3390/cells10020249
10.1016/j.mcn.2013.07.007
10.3390/ijms21249593
10.1016/B978-0-12-802973-2.00013-6
10.1016/j.nbd.2018.03.010
10.1016/j.bbrc.2010.02.150
10.1007/978-3-030-11096-3_6
10.1073/pnas.1202922109
10.1097/WCO.0000000000000862
10.1002/stem.201
10.1126/science.1158799
10.1016/j.neuron.2013.10.015
10.1007/s12015-021-10200-3
10.1016/j.cell.2017.10.011
10.1126/scitranslmed.3004052
10.1016/j.cell.2020.09.020
10.1016/j.cell.2007.11.019
10.1126/science.1086071
10.1016/j.neurol.2017.04.003
10.1007/s00415-019-09652-y
10.1007/s40778-016-0049-1
10.1007/s12035-020-02006-0
10.1001/jamaneurol.2021.4893
10.1016/j.ebiom.2019.11.026
10.1038/s41419-018-0990-2
10.1016/j.stemcr.2020.03.023
10.3390/ijms22031413
10.1002/cne.23578
10.1038/s41593-022-01040-6
10.1002/adbi.202000223
10.1016/j.reth.2019.07.002
10.2183/pjab.85.348
10.1002/stem.2388
10.1038/nbt1374
10.1016/j.neuron.2016.09.015
10.1126/science.1239278
10.1007/s12192-019-01064-1
10.1038/s41598-022-12098-4
10.3390/ijms21103464
10.1016/j.stem.2011.07.014
10.1016/j.cell.2018.03.004
10.1038/s41598-020-69845-8
10.1136/bmjopen-2019-033131
10.1056/NEJMoa2204705
10.1016/j.tins.2021.04.008
10.1038/nature14974
10.1038/s41593-019-0498-9
10.1016/j.neulet.2021.135911
10.1016/j.stemcr.2017.12.018
10.1186/s13287-018-1048-1
10.1098/rstb.2014.0367
10.1111/acel.13549
10.1038/nature21029
10.1016/j.brainres.2015.10.003
10.1016/j.tips.2019.12.002
10.3390/cells10020240
10.3390/ijms232113462
10.15252/embr.201642402
10.1016/j.cell.2006.07.024
10.1016/j.stem.2014.03.004
10.1038/s41467-018-05127-2
10.1002/sctm.20-0522
10.4103/1673-5374.332123
10.1097/01.NAJ.0000911516.31267.67
10.3389/fncel.2016.00290
10.1002/prp2.983
10.1016/j.stemcr.2014.05.017
10.1016/j.neuron.2011.09.010
10.1016/j.eclinm.2022.101707
10.1126/scitranslmed.aaf3962
10.1056/NEJM199403033300901
10.1186/s13041-017-0300-4
10.1016/j.stem.2021.12.008
10.15252/emmm.201809423
10.1038/nature14973
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Keywords induced pluripotent stem cells
drug screening
amyotrophic lateral sclerosis
cell therapy
disease modeling
Language English
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These authors contributed equally to this work.
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PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Cells (Basel, Switzerland)
PublicationTitleAlternate Cells
PublicationYear 2023
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References ref_94
Gubert (ref_75) 2019; 37
Morotz (ref_61) 2022; 21
Ohnuki (ref_110) 2015; 370
Chen (ref_41) 2016; 17
Tsai (ref_74) 2022; 12
Choi (ref_122) 2020; 11
Pender (ref_2) 2020; 33
Wainger (ref_121) 2021; 78
Imamura (ref_126) 2021; 89
Takahashi (ref_29) 2007; 131
Lee (ref_43) 2017; 1656
ref_96
Kerk (ref_90) 2022; 17
ref_18
Bensimon (ref_24) 1994; 330
ref_15
Freibaum (ref_59) 2015; 525
Ronchi (ref_47) 2021; 5
Fujimori (ref_118) 2018; 24
Renton (ref_10) 2011; 72
Spijkers (ref_123) 2021; 157
Sun (ref_78) 2018; 9
Tsuburaya (ref_112) 2018; 9
Sareen (ref_97) 2014; 522
Chen (ref_50) 2014; 14
Liu (ref_104) 2022; 17
Hofweber (ref_68) 2018; 173
Deneault (ref_125) 2022; 203
Lu (ref_58) 2016; 92
Bristol (ref_81) 1996; 39
Popescu (ref_99) 2013; 2
Nizzardo (ref_100) 2014; 23
Sleutjes (ref_120) 2022; 10
Zeng (ref_17) 2020; 10
Niedermeyer (ref_22) 2019; 155
Zhou (ref_34) 2009; 27
Burkhardt (ref_76) 2013; 56
Talbott (ref_5) 2016; 138
Dafinca (ref_1) 2016; 34
Imamura (ref_117) 2022; 53
Feldman (ref_3) 2022; 400
Zhang (ref_11) 2015; 525
Miller (ref_27) 2022; 387
Higelin (ref_67) 2016; 10
Imamura (ref_52) 2017; 9
Picchiarelli (ref_73) 2019; 22
Namboori (ref_124) 2021; 16
Morimoto (ref_119) 2019; 11
Hayashi (ref_107) 2019; 1123
Barres (ref_92) 2008; 60
Clement (ref_95) 2003; 302
Kim (ref_36) 2009; 4
Lenglet (ref_20) 2017; 173
ref_89
Alves (ref_77) 2015; 9
Fusaki (ref_38) 2009; 85
Kato (ref_8) 2005; 110
Egawa (ref_64) 2012; 4
Liu (ref_70) 2015; 16
Yu (ref_66) 2020; 183
Hou (ref_40) 2013; 341
Yakubov (ref_37) 2010; 394
Witzel (ref_25) 2022; 79
Dimos (ref_30) 2008; 321
Reber (ref_69) 2021; 49
Ferraiuolo (ref_31) 2021; 755
Wainger (ref_80) 2014; 7
Bilican (ref_63) 2012; 109
Almeida (ref_55) 2013; 126
Eitan (ref_91) 2022; 25
Costa (ref_12) 2010; 9
Feng (ref_88) 2022; 2022
Giacomelli (ref_109) 2022; 29
Okano (ref_111) 2020; 41
Donnelly (ref_54) 2013; 80
Masrori (ref_14) 2020; 27
Sakae (ref_57) 2018; 6
Guo (ref_72) 2017; 8
Kreiter (ref_65) 2018; 115
Baxi (ref_79) 2022; 25
Takahashi (ref_28) 2006; 126
Zhang (ref_39) 2022; 62
Birger (ref_85) 2019; 50
Huang (ref_21) 2020; 7
Kondo (ref_98) 2014; 3
Kuta (ref_114) 2020; 25
Zou (ref_53) 2017; 88
Madill (ref_84) 2017; 10
Rajpurohit (ref_87) 2020; 57
Westergard (ref_56) 2019; 11
Dafinca (ref_60) 2020; 14
Fang (ref_16) 2016; 126
Imamura (ref_116) 2019; 9
Fang (ref_113) 2019; 103
Phatnani (ref_13) 2021; 44
Son (ref_46) 2011; 9
Xu (ref_4) 2020; 267
Zhao (ref_86) 2020; 68
Liddelow (ref_93) 2017; 541
Rosati (ref_102) 2018; 9
Ray (ref_32) 2021; 17
Nakagawa (ref_33) 2008; 26
Kaur (ref_9) 2016; 577
Rothstein (ref_23) 2017; 171
Bar (ref_108) 2019; 38
Haraguchi (ref_42) 2022; 30
Kiskinis (ref_51) 2014; 14
ref_103
Lamas (ref_44) 2021; 1
Tyzack (ref_82) 2016; 2
ref_106
Kato (ref_115) 2021; 132
Sterneckert (ref_45) 2022; 10
Sun (ref_105) 2021; 10
Toma (ref_48) 2015; 35
Muffat (ref_83) 2016; 22
Rosen (ref_7) 1993; 362
Nicholson (ref_19) 2021; 22
Haase (ref_35) 2009; 5
ref_49
Marrone (ref_71) 2018; 10
Neuro (ref_62) 2021; 24
Nizzardo (ref_101) 2016; 25
Aschenbrenner (ref_26) 2023; 123
ref_6
References_xml – volume: 126
  start-page: 385
  year: 2013
  ident: ref_55
  article-title: Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-013-1149-y
– volume: 9
  start-page: 289
  year: 2015
  ident: ref_77
  article-title: Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration
  publication-title: Front. Cell Neurosci.
  doi: 10.3389/fncel.2015.00289
– volume: 2
  start-page: 167
  year: 2013
  ident: ref_99
  article-title: Neural progenitors derived from human induced pluripotent stem cells survive and differentiate upon transplantation into a rat model of amyotrophic lateral sclerosis
  publication-title: Stem Cells Transl. Med.
  doi: 10.5966/sctm.2012-0042
– ident: ref_18
  doi: 10.3390/biomedicines9070753
– volume: 78
  start-page: 186
  year: 2021
  ident: ref_121
  article-title: Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2020.4300
– volume: 157
  start-page: 393
  year: 2021
  ident: ref_123
  article-title: Neuromuscular junction-on-a-chip: ALS disease modeling and read-out development in microfluidic devices
  publication-title: J. Neurochem.
  doi: 10.1111/jnc.15289
– volume: 362
  start-page: 59
  year: 1993
  ident: ref_7
  article-title: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
  publication-title: Nature
  doi: 10.1038/362059a0
– volume: 25
  start-page: 3152
  year: 2016
  ident: ref_101
  article-title: iPSC-derived LewisX+CXCR4+beta1-integrin+ neural stem cells improve the amyotrophic lateral sclerosis phenotype by preserving motor neurons and muscle innervation in human and rodent models
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddw163
– volume: 5
  start-page: 434
  year: 2009
  ident: ref_35
  article-title: Generation of induced pluripotent stem cells from human cord blood
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2009.08.021
– volume: 60
  start-page: 430
  year: 2008
  ident: ref_92
  article-title: The mystery and magic of glia: A perspective on their roles in health and disease
  publication-title: Neuron
  doi: 10.1016/j.neuron.2008.10.013
– volume: 25
  start-page: 226
  year: 2022
  ident: ref_79
  article-title: Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-021-01006-0
– volume: 35
  start-page: 1291
  year: 2015
  ident: ref_48
  article-title: Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2126-14.2015
– volume: 7
  start-page: 1103
  year: 2020
  ident: ref_21
  article-title: Longitudinal biomarkers in amyotrophic lateral sclerosis
  publication-title: Ann. Clin. Transl. Neurol.
  doi: 10.1002/acn3.51078
– volume: 7
  start-page: 1
  year: 2014
  ident: ref_80
  article-title: Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.03.019
– volume: 14
  start-page: 796
  year: 2014
  ident: ref_50
  article-title: Modeling ALS with iPSCs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.02.004
– volume: 17
  start-page: 678
  year: 2022
  ident: ref_90
  article-title: Homozygous ALS-linked FUS P525L mutations cell-autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2022.01.004
– volume: 1
  start-page: 773424
  year: 2021
  ident: ref_44
  article-title: Harnessing the Potential of Human Pluripotent Stem Cell-Derived Motor Neurons for Drug Discovery in Amyotrophic Lateral Sclerosis: From the Clinic to the Laboratory and Back to the Patient
  publication-title: Front. Drug Discov.
  doi: 10.3389/fddsv.2021.773424
– volume: 103
  start-page: 802
  year: 2019
  ident: ref_113
  article-title: Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.05.048
– volume: 30
  start-page: 101267
  year: 2022
  ident: ref_42
  article-title: Pramef12 enhances reprogramming into naive iPS cells
  publication-title: Biochem. Biophys. Rep.
– volume: 68
  start-page: 1046
  year: 2020
  ident: ref_86
  article-title: Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology
  publication-title: Glia
  doi: 10.1002/glia.23761
– volume: 11
  start-page: 888
  year: 2020
  ident: ref_122
  article-title: Prevention of mitochondrial impairment by inhibition of protein phosphatase 1 activity in amyotrophic lateral sclerosis
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-03102-8
– volume: 203
  start-page: 297
  year: 2022
  ident: ref_125
  article-title: A streamlined CRISPR workflow to introduce mutations and generate isogenic iPSCs for modeling amyotrophic lateral sclerosis
  publication-title: Methods
  doi: 10.1016/j.ymeth.2021.09.002
– volume: 22
  start-page: 186
  year: 2021
  ident: ref_19
  article-title: The human gut microbiota in people with amyotrophic lateral sclerosis
  publication-title: Amyotroph Lateral Scler Front. Degener.
  doi: 10.1080/21678421.2020.1828475
– volume: 16
  start-page: 223
  year: 2015
  ident: ref_70
  article-title: The fused in sarcoma protein forms cytoplasmic aggregates in motor neurons derived from integration-free induced pluripotent stem cells generated from a patient with familial amyotrophic lateral sclerosis carrying the FUS-P525L mutation
  publication-title: Neurogenetics
  doi: 10.1007/s10048-015-0448-y
– volume: 400
  start-page: 1363
  year: 2022
  ident: ref_3
  article-title: Amyotrophic lateral sclerosis
  publication-title: Lancet
  doi: 10.1016/S0140-6736(22)01272-7
– volume: 126
  start-page: 771
  year: 2016
  ident: ref_16
  article-title: Potential role of gut microbiota and tissue barriers in Parkinson’s disease and amyotrophic lateral sclerosis
  publication-title: Int. J. Neurosci.
  doi: 10.3109/00207454.2015.1096271
– volume: 89
  start-page: 1226
  year: 2021
  ident: ref_126
  article-title: Prediction Model of Amyotrophic Lateral Sclerosis by Deep Learning with Patient Induced Pluripotent Stem Cells
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.26047
– ident: ref_49
  doi: 10.3390/antiox7020025
– volume: 155
  start-page: 401
  year: 2019
  ident: ref_22
  article-title: Respiratory Failure in Amyotrophic Lateral Sclerosis
  publication-title: Chest
  doi: 10.1016/j.chest.2018.06.035
– volume: 16
  start-page: 3020
  year: 2021
  ident: ref_124
  article-title: Single-cell transcriptomics identifies master regulators of neurodegeneration in SOD1 ALS iPSC-derived motor neurons
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2021.10.010
– volume: 110
  start-page: 101
  year: 2005
  ident: ref_8
  article-title: Redox system expression in the motor neurons in amyotrophic lateral sclerosis (ALS): Immunohistochemical studies on sporadic ALS, superoxide dismutase 1 (SOD1)-mutated familial ALS, and SOD1-mutated ALS animal models
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-005-1019-3
– volume: 6
  start-page: 63
  year: 2018
  ident: ref_57
  article-title: Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease
  publication-title: Acta Neuropathol. Commun.
  doi: 10.1186/s40478-018-0564-7
– volume: 22
  start-page: 1358
  year: 2016
  ident: ref_83
  article-title: Efficient derivation of microglia-like cells from human pluripotent stem cells
  publication-title: Nat. Med.
  doi: 10.1038/nm.4189
– volume: 38
  start-page: e101033
  year: 2019
  ident: ref_108
  article-title: Epigenetic aberrations in human pluripotent stem cells
  publication-title: EMBO J.
  doi: 10.15252/embj.2018101033
– volume: 24
  start-page: 103221
  year: 2021
  ident: ref_62
  article-title: An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients
  publication-title: iScience
  doi: 10.1016/j.isci.2021.103221
– volume: 88
  start-page: 540
  year: 2017
  ident: ref_53
  article-title: Genetic epidemiology of amyotrophic lateral sclerosis: A systematic review and meta-analysis
  publication-title: J. Neurol Neurosurg. Psychiatry
  doi: 10.1136/jnnp-2016-315018
– volume: 9
  start-page: 764
  year: 2010
  ident: ref_12
  article-title: Diagnosis, pathogenesis and therapeutic targets in amyotrophic lateral sclerosis
  publication-title: CNS Neurol. Disord. Drug Targets
  doi: 10.2174/187152710793237502
– volume: 132
  start-page: 640
  year: 2021
  ident: ref_115
  article-title: Niclosamide affects intracellular TDP-43 distribution in motor neurons, activates mitophagy, and attenuates morphological changes under stress
  publication-title: J. Biosci. Bioeng.
  doi: 10.1016/j.jbiosc.2021.06.015
– volume: 49
  start-page: 7713
  year: 2021
  ident: ref_69
  article-title: The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkab582
– volume: 37
  start-page: 101448
  year: 2019
  ident: ref_75
  article-title: Generation of four patient-specific pluripotent induced stem cell lines from two Brazilian patients with amyotrophic lateral sclerosis and two healthy subjects
  publication-title: Stem Cell Res.
  doi: 10.1016/j.scr.2019.101448
– volume: 4
  start-page: 472
  year: 2009
  ident: ref_36
  article-title: Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2009.05.005
– volume: 23
  start-page: 342
  year: 2014
  ident: ref_100
  article-title: Minimally invasive transplantation of iPSC-derived ALDHhiSSCloVLA4+ neural stem cells effectively improves the phenotype of an amyotrophic lateral sclerosis model
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddt425
– volume: 24
  start-page: 1579
  year: 2018
  ident: ref_118
  article-title: Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0140-5
– volume: 27
  start-page: 1918
  year: 2020
  ident: ref_14
  article-title: Amyotrophic lateral sclerosis: A clinical review
  publication-title: Eur. J. Neurol.
  doi: 10.1111/ene.14393
– volume: 62
  start-page: 102788
  year: 2022
  ident: ref_39
  article-title: Generation of an induced pluripotent stem cell line (ZZUi034-A) from a 65 year old Chinese female donor with sendai virus reprogramming protocol
  publication-title: Stem Cell Res.
  doi: 10.1016/j.scr.2022.102788
– ident: ref_89
  doi: 10.1101/2021.12.30.474573
– volume: 39
  start-page: 676
  year: 1996
  ident: ref_81
  article-title: Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex
  publication-title: Ann. Neurol.
  doi: 10.1002/ana.410390519
– volume: 577
  start-page: 109
  year: 2016
  ident: ref_9
  article-title: Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis
  publication-title: Gene
  doi: 10.1016/j.gene.2015.11.049
– volume: 8
  start-page: 861
  year: 2017
  ident: ref_72
  article-title: HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00911-y
– ident: ref_96
  doi: 10.3390/cells10020249
– volume: 56
  start-page: 355
  year: 2013
  ident: ref_76
  article-title: A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells
  publication-title: Mol. Cell Neurosci.
  doi: 10.1016/j.mcn.2013.07.007
– ident: ref_103
  doi: 10.3390/ijms21249593
– volume: 138
  start-page: 225
  year: 2016
  ident: ref_5
  article-title: The epidemiology of amyotrophic lateral sclerosis
  publication-title: Handb. Clin. Neurol.
  doi: 10.1016/B978-0-12-802973-2.00013-6
– volume: 115
  start-page: 167
  year: 2018
  ident: ref_65
  article-title: Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2018.03.010
– volume: 394
  start-page: 189
  year: 2010
  ident: ref_37
  article-title: Reprogramming of human fibroblasts to pluripotent stem cells using mRNA of four transcription factors
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2010.02.150
– volume: 1123
  start-page: 71
  year: 2019
  ident: ref_107
  article-title: Pluripotent Stem Cell Heterogeneity
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-030-11096-3_6
– volume: 109
  start-page: 5803
  year: 2012
  ident: ref_63
  article-title: Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.1202922109
– volume: 33
  start-page: 649
  year: 2020
  ident: ref_2
  article-title: Cognitive and behavioural impairment in amyotrophic lateral sclerosis
  publication-title: Curr. Opin. Neurol.
  doi: 10.1097/WCO.0000000000000862
– volume: 27
  start-page: 2667
  year: 2009
  ident: ref_34
  article-title: Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells
  publication-title: Stem Cells
  doi: 10.1002/stem.201
– volume: 321
  start-page: 1218
  year: 2008
  ident: ref_30
  article-title: Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons
  publication-title: Science
  doi: 10.1126/science.1158799
– volume: 80
  start-page: 415
  year: 2013
  ident: ref_54
  article-title: RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention
  publication-title: Neuron
  doi: 10.1016/j.neuron.2013.10.015
– volume: 17
  start-page: 1954
  year: 2021
  ident: ref_32
  article-title: An Overview on Promising Somatic Cell Sources Utilized for the Efficient Generation of Induced Pluripotent Stem Cells
  publication-title: Stem Cell Rev. Rep.
  doi: 10.1007/s12015-021-10200-3
– volume: 171
  start-page: 725
  year: 2017
  ident: ref_23
  article-title: Edaravone: A new drug approved for ALS
  publication-title: Cell
  doi: 10.1016/j.cell.2017.10.011
– volume: 4
  start-page: 145ra104
  year: 2012
  ident: ref_64
  article-title: Drug screening for ALS using patient-specific induced pluripotent stem cells
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3004052
– volume: 183
  start-page: 636
  year: 2020
  ident: ref_66
  article-title: TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
  publication-title: Cell
  doi: 10.1016/j.cell.2020.09.020
– volume: 10
  start-page: 1089970
  year: 2022
  ident: ref_45
  article-title: Progress and challenges in directing the differentiation of human iPSCs into spinal motor neurons
  publication-title: Front. Cell Dev. Biol.
– volume: 131
  start-page: 861
  year: 2007
  ident: ref_29
  article-title: Induction of pluripotent stem cells from adult human fibroblasts by defined factors
  publication-title: Cell
  doi: 10.1016/j.cell.2007.11.019
– volume: 302
  start-page: 113
  year: 2003
  ident: ref_95
  article-title: Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
  publication-title: Science
  doi: 10.1126/science.1086071
– volume: 2022
  start-page: 6483582
  year: 2022
  ident: ref_88
  article-title: Autophagy-Mediated Inflammatory Cytokine Secretion in Sporadic ALS Patient iPSC-Derived Astrocytes
  publication-title: Oxid. Med. Cell Longev.
– volume: 173
  start-page: 280
  year: 2017
  ident: ref_20
  article-title: Amyotrophic lateral sclerosis or not: Keys for the diagnosis
  publication-title: Rev. Neurol.
  doi: 10.1016/j.neurol.2017.04.003
– volume: 267
  start-page: 944
  year: 2020
  ident: ref_4
  article-title: Global variation in prevalence and incidence of amyotrophic lateral sclerosis: A systematic review and meta-analysis
  publication-title: J. Neurol.
  doi: 10.1007/s00415-019-09652-y
– volume: 2
  start-page: 236
  year: 2016
  ident: ref_82
  article-title: Human Stem Cell-Derived Astrocytes: Specification and Relevance for Neurological Disorders
  publication-title: Curr. Stem Cell Rep.
  doi: 10.1007/s40778-016-0049-1
– volume: 57
  start-page: 4117
  year: 2020
  ident: ref_87
  article-title: Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1(L39R) Linked Amyotrophic Lateral Sclerosis
  publication-title: Mol. Neurobiol.
  doi: 10.1007/s12035-020-02006-0
– volume: 79
  start-page: 121
  year: 2022
  ident: ref_25
  article-title: Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients with Amyotrophic Lateral Sclerosis
  publication-title: JAMA Neurol.
  doi: 10.1001/jamaneurol.2021.4893
– volume: 50
  start-page: 274
  year: 2019
  ident: ref_85
  article-title: Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity
  publication-title: EBioMedicine
  doi: 10.1016/j.ebiom.2019.11.026
– volume: 9
  start-page: 937
  year: 2018
  ident: ref_102
  article-title: Establishment of stable iPS-derived human neural stem cell lines suitable for cell therapies
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-018-0990-2
– volume: 14
  start-page: 892
  year: 2020
  ident: ref_60
  article-title: Impairment of Mitochondrial Calcium Buffering Links Mutations in C9ORF72 and TARDBP in iPS-Derived Motor Neurons from Patients with ALS/FTD
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2020.03.023
– ident: ref_15
  doi: 10.3390/ijms22031413
– volume: 522
  start-page: 2707
  year: 2014
  ident: ref_97
  article-title: Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord
  publication-title: J. Comp. Neurol.
  doi: 10.1002/cne.23578
– volume: 25
  start-page: 433
  year: 2022
  ident: ref_91
  article-title: Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3’UTR protect against ALS
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-022-01040-6
– volume: 5
  start-page: e2000223
  year: 2021
  ident: ref_47
  article-title: Electrophysiological Phenotype Characterization of Human iPSC-Derived Neuronal Cell Lines by Means of High-Density Microelectrode Arrays
  publication-title: Adv. Biol.
  doi: 10.1002/adbi.202000223
– volume: 11
  start-page: 143
  year: 2019
  ident: ref_119
  article-title: Ropinirole hydrochloride remedy for amyotrophic lateral sclerosis—Protocol for a randomized, double-blind, placebo-controlled, single-center, and open-label continuation phase I/IIa clinical trial (ROPALS trial)
  publication-title: Regen. Ther.
  doi: 10.1016/j.reth.2019.07.002
– volume: 85
  start-page: 348
  year: 2009
  ident: ref_38
  article-title: Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome
  publication-title: Proc. Jpn. Acad. Ser. B Phys. Biol. Sci.
  doi: 10.2183/pjab.85.348
– volume: 34
  start-page: 2063
  year: 2016
  ident: ref_1
  article-title: C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
  publication-title: Stem Cells
  doi: 10.1002/stem.2388
– volume: 26
  start-page: 101
  year: 2008
  ident: ref_33
  article-title: Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1374
– volume: 92
  start-page: 383
  year: 2016
  ident: ref_58
  article-title: Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.09.015
– volume: 341
  start-page: 651
  year: 2013
  ident: ref_40
  article-title: Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds
  publication-title: Science
  doi: 10.1126/science.1239278
– volume: 25
  start-page: 173
  year: 2020
  ident: ref_114
  article-title: Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models
  publication-title: Cell Stress Chaperones
  doi: 10.1007/s12192-019-01064-1
– volume: 12
  start-page: 8180
  year: 2022
  ident: ref_74
  article-title: Nuclear RNA transcript levels modulate nucleocytoplasmic distribution of ALS/FTD-associated protein FUS
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-022-12098-4
– ident: ref_6
  doi: 10.3390/ijms21103464
– volume: 9
  start-page: 205
  year: 2011
  ident: ref_46
  article-title: Conversion of mouse and human fibroblasts into functional spinal motor neurons
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2011.07.014
– volume: 173
  start-page: 706
  year: 2018
  ident: ref_68
  article-title: Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.004
– volume: 10
  start-page: 12998
  year: 2020
  ident: ref_17
  article-title: The alteration of gut microbiome and metabolism in amyotrophic lateral sclerosis patients
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-020-69845-8
– volume: 9
  start-page: e033131
  year: 2019
  ident: ref_116
  article-title: Induced pluripotent stem cell-based Drug Repurposing for Amyotrophic lateral sclerosis Medicine (iDReAM) study: Protocol for a phase I dose escalation study of bosutinib for amyotrophic lateral sclerosis patients
  publication-title: BMJ Open
  doi: 10.1136/bmjopen-2019-033131
– volume: 387
  start-page: 1099
  year: 2022
  ident: ref_27
  article-title: Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2204705
– volume: 44
  start-page: 658
  year: 2021
  ident: ref_13
  article-title: Non-cell-autonomous pathogenic mechanisms in amyotrophic lateral sclerosis
  publication-title: Trends Neurosci.
  doi: 10.1016/j.tins.2021.04.008
– volume: 525
  start-page: 129
  year: 2015
  ident: ref_59
  article-title: GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
  publication-title: Nature
  doi: 10.1038/nature14974
– volume: 22
  start-page: 1793
  year: 2019
  ident: ref_73
  article-title: FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-019-0498-9
– volume: 755
  start-page: 135911
  year: 2021
  ident: ref_31
  article-title: Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets
  publication-title: Neurosci. Lett.
  doi: 10.1016/j.neulet.2021.135911
– volume: 10
  start-page: 375
  year: 2018
  ident: ref_71
  article-title: Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2017.12.018
– volume: 9
  start-page: 315
  year: 2018
  ident: ref_78
  article-title: Modeling hallmark pathology using motor neurons derived from the family and sporadic amyotrophic lateral sclerosis patient-specific iPS cells
  publication-title: Stem Cell Res. Ther.
  doi: 10.1186/s13287-018-1048-1
– volume: 370
  start-page: 20140367
  year: 2015
  ident: ref_110
  article-title: Present and future challenges of induced pluripotent stem cells
  publication-title: Philos. Trans. R. Soc. Lond. B Biol. Sci.
  doi: 10.1098/rstb.2014.0367
– volume: 21
  start-page: e13549
  year: 2022
  ident: ref_61
  article-title: Disruption of ER-mitochondria tethering and signalling in C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia
  publication-title: Aging Cell
  doi: 10.1111/acel.13549
– volume: 541
  start-page: 481
  year: 2017
  ident: ref_93
  article-title: Neurotoxic reactive astrocytes are induced by activated microglia
  publication-title: Nature
  doi: 10.1038/nature21029
– volume: 1656
  start-page: 88
  year: 2017
  ident: ref_43
  article-title: Modeling ALS and FTD with iPSC-derived neurons
  publication-title: Brain Res.
  doi: 10.1016/j.brainres.2015.10.003
– volume: 41
  start-page: 99
  year: 2020
  ident: ref_111
  article-title: Ropinirole, a New ALS Drug Candidate Developed Using iPSCs
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2019.12.002
– ident: ref_94
  doi: 10.3390/cells10020240
– ident: ref_106
  doi: 10.3390/ijms232113462
– volume: 17
  start-page: 1641
  year: 2016
  ident: ref_41
  article-title: Gadd45a is a heterochromatin relaxer that enhances iPS cell generation
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201642402
– volume: 126
  start-page: 663
  year: 2006
  ident: ref_28
  article-title: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
  publication-title: Cell
  doi: 10.1016/j.cell.2006.07.024
– volume: 14
  start-page: 781
  year: 2014
  ident: ref_51
  article-title: Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2014.03.004
– volume: 9
  start-page: 2668
  year: 2018
  ident: ref_112
  article-title: A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-05127-2
– volume: 10
  start-page: S31
  year: 2021
  ident: ref_105
  article-title: Neuronal cell-based medicines from pluripotent stem cells: Development, production, and preclinical assessment
  publication-title: Stem Cells Transl. Med.
  doi: 10.1002/sctm.20-0522
– volume: 17
  start-page: 1633
  year: 2022
  ident: ref_104
  article-title: Motor neuron replacement therapy for amyotrophic lateral sclerosis
  publication-title: Neural Regen. Res.
  doi: 10.4103/1673-5374.332123
– volume: 123
  start-page: 22
  year: 2023
  ident: ref_26
  article-title: New Drug Approved For ALS
  publication-title: Am. J. Nurs.
  doi: 10.1097/01.NAJ.0000911516.31267.67
– volume: 10
  start-page: 290
  year: 2016
  ident: ref_67
  article-title: FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons
  publication-title: Front. Cell Neurosci.
  doi: 10.3389/fncel.2016.00290
– volume: 10
  start-page: e00983
  year: 2022
  ident: ref_120
  article-title: Acute retigabine-induced effects on myelinated motor axons in amyotrophic lateral sclerosis
  publication-title: Pharmacol. Res. Perspect.
  doi: 10.1002/prp2.983
– volume: 3
  start-page: 242
  year: 2014
  ident: ref_98
  article-title: Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of ALS mice
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2014.05.017
– volume: 72
  start-page: 257
  year: 2011
  ident: ref_10
  article-title: A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.09.010
– volume: 53
  start-page: 101707
  year: 2022
  ident: ref_117
  article-title: Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial
  publication-title: EClinicalMedicine
  doi: 10.1016/j.eclinm.2022.101707
– volume: 9
  start-page: eaaf3962
  year: 2017
  ident: ref_52
  article-title: The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aaf3962
– volume: 330
  start-page: 585
  year: 1994
  ident: ref_24
  article-title: A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM199403033300901
– volume: 10
  start-page: 22
  year: 2017
  ident: ref_84
  article-title: Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
  publication-title: Mol. Brain
  doi: 10.1186/s13041-017-0300-4
– volume: 29
  start-page: 11
  year: 2022
  ident: ref_109
  article-title: Human stem cell models of neurodegeneration: From basic science of amyotrophic lateral sclerosis to clinical translation
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2021.12.008
– volume: 11
  start-page: e9423
  year: 2019
  ident: ref_56
  article-title: Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.201809423
– volume: 525
  start-page: 56
  year: 2015
  ident: ref_11
  article-title: The C9orf72 repeat expansion disrupts nucleocytoplasmic transport
  publication-title: Nature
  doi: 10.1038/nature14973
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Snippet Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that results in the loss of motor function in the central nervous system (CNS)...
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SubjectTerms Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - genetics
Amyotrophic Lateral Sclerosis - metabolism
Amyotrophic Lateral Sclerosis - therapy
Animals
Care and treatment
Cell differentiation
Cell lines
Cell therapy
Cell- and Tissue-Based Therapy
Cellular therapy
Central nervous system
Development and progression
Disease
disease modeling
Drug screening
Efficiency
Family medical history
Fibroblasts
Genotypes
Glial cells
Health aspects
induced pluripotent stem cells
Induced Pluripotent Stem Cells - metabolism
Inhibitory postsynaptic potentials
Methods
Mutation
Nervous system
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neuronal-glial interactions
Neurons - metabolism
Oxidative stress
Pathogenesis
Phenotypes
Physiological aspects
Pluripotency
Proteins
Review
Somatic cells
Stem cells
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Title Induced Pluripotent Stem Cells and Their Applications in Amyotrophic Lateral Sclerosis
URI https://www.ncbi.nlm.nih.gov/pubmed/36980310
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Volume 12
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