Ciclopirox Ethanolamine Preserves the Immature State of Human HSCs by Mediating Intracellular Iron Content

• Published in: Blood advances Vol. 7; no. 24; pp. 7407 - 7417
• Main Authors: Safaee Talkhoncheh, Mehrnaz, Baudet, Aurélie, Ek, Fredrik, Subramaniam, Agatheeswaran, Kao, Yun-Ruei, Miharada, Natsumi, Karlsson, Christine, Oburoglu, Leal, Rydström, Anna, Zemaitis, Kristijonas, Alattar, Abdul Ghani, Rak, Justyna, Pietras, Kristian, Olsson, Roger, Will, Britta, Larsson, Jonas
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.12.2023; The American Society of Hematology
• Subjects: Antigens, CD34 - metabolism; Basic Medicine; Cell and Molecular Biology; Cell- och molekylärbiologi; Ciclopirox - metabolism; Ciclopirox - pharmacology; Ethanolamines - metabolism; Ethanolamines - pharmacology; Hematopoiesis and Stem Cells; Hematopoietic Stem Cells - metabolism; Humans; Iron - metabolism; Medical and Health Sciences; Medical Biotechnology; Medicin och hälsovetenskap; Medicinsk bioteknologi; Medicinska och farmaceutiska grundvetenskaper

•Ciclopirox Ethanolamine (CPX) is a regulator of HSCs and preserves the stem cell state in culture.•CPX-induced HSC maintenance is mediated by intracellular iron chelation, which restricts respiratory capacity and proliferation. Culture conditions in which hematopoietic stem cells (HSCs) can be expa...