Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases

• Published in: Biology (Basel, Switzerland) Vol. 10; no. 2; p. 163
• Main Authors: Gupta, Swapnil, You, Panpan, SenGupta, Tanima, Nilsen, Hilde, Sharma, Kulbhushan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 19.02.2021; MDPI AG
• Subjects: ALS; Alzheimer; DNA damage response; neurodegeneration; oxidative stress; PARP; Review; DNA damage response; neuroinflammation; ALS; neurodegeneration; PARP; cGAS-STING; Alzheimer; Parkinson; oxidative stress

Genomic integrity is maintained by DNA repair and the DNA damage response (DDR). Defects in certain DNA repair genes give rise to many rare progressive neurodegenerative diseases (NDDs), such as ocular motor ataxia, Huntington disease (HD), and spinocerebellar ataxias (SCA). Dysregulation or dysfunc...