Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis

• Published in: Biomarker research Vol. 11; no. 1; p. 46
• Main Authors: Marañón, Patricia, Isaza, Stephania C, Fernández-García, Carlos Ernesto, Rey, Esther, Gallego-Durán, Rocío, Montero-Vallejo, Rocío, de Cía, Javier Rodríguez, Ampuero, Javier, Valverde, Ángela M, Romero-Gómez, Manuel, García-Monzón, Carmelo, González-Rodríguez, Águeda
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 27.04.2023; BioMed Central; BMC
• Subjects: Algorithms; Analysis; Animal experimentation; Animal models; Animals; Antibiotics; Bile ducts; Biomarkers; Biopsy; BMP8A; Bone morphogenetic proteins; Cell culture; Diet; Fibrosis; Glucose; Health aspects; Hepatic stellate cells; Hepatitis; Humidity; Liver; Liver cancer; Liver cirrhosis; Liver diseases; Liver fibrosis; Medical research; Medicine, Experimental; Morbidity; Mortality; mRNA; Non-invasive diagnosis; Patients; Risk factors; Secretion; Transforming growth factors; Taiwan; Spain; United States > US; BMP8A; Bone morphogenetic proteins; Hepatic stellate cells; Non-invasive diagnosis; Liver fibrosis

Advanced hepatic fibrosis is the main risk factor of liver-related morbidity and mortality in patients with chronic liver disease. In this study, we assessed the potential role of bone morphogenetic protein 8A (BMP8A) as a novel target involved in liver fibrosis progression. Histological assessment...