Ciglitazone inhibits plasmin-induced proinflammatory monocyte activation via modulation of p38 MAP kinase activity

• Published in: Thrombosis and haemostasis Vol. 88; no. 2; p. 274
• Main Authors: Syrovets, Tatiana, Schüle, Almut, Jendrach, Marina, Büchele, Berthold, Simmet, Thomas
• Format: Journal Article
• Language: English
• Published: Germany 01.08.2002
• Subjects: Chemotaxis, Leukocyte - drug effects; Fibrinolysin - antagonists & inhibitors; Fibrinolysin - physiology; Humans; Inflammation - pathology; Interleukin-1 - secretion; Mitogen-Activated Protein Kinases - drug effects; Mitogen-Activated Protein Kinases - metabolism; Monocytes - cytology; Monocytes - drug effects; Monocytes - metabolism; p38 Mitogen-Activated Protein Kinases; Phosphorylation - drug effects; Receptors, Cytoplasmic and Nuclear - agonists; Thiazoles - pharmacology; Thiazolidinediones; Transcription Factors - agonists; Tumor Necrosis Factor-alpha - drug effects; Tumor Necrosis Factor-alpha - secretion

Plasmin triggers chemotaxis and NF-kappa B- and AP-1-mediated proinflammatory gene expression in human peripheral monocytes (PM). Compared with macrophages and dendritic cells, PM express mainly the peroxisome proliferator-activated receptor (PPAR) gamma and traces of PPAR alpha as detected by semiq...