Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19

• Published in: Cell host & microbe Vol. 29; no. 2; pp. 222 - 235.e4
• Main Authors: Guo, Qirui, Zhao, Yingchi, Li, Junhong, Liu, Jiangning, Yang, Xiuhong, Guo, Xuefei, Kuang, Ming, Xia, Huawei, Zhang, Zeming, Cao, Lili, Luo, Yujie, Bao, Linlin, Wang, Xiao, Wei, Xuemei, Deng, Wei, Wang, Nan, Chen, Luoying, Chen, Jingxuan, Zhu, Hua, Gao, Ran, Qin, Chuan, Wang, Xiangxi, You, Fuping
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.02.2021; The Authors. Published by Elsevier Inc
• Subjects: aberrant neutrophils; Alarmins - pharmacology; Animals; Antiviral Agents - pharmacology; COVID-19 - metabolism; COVID-19 - virology; COVID-19 Drug Treatment; Disease Models, Animal; Female; Humans; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils - drug effects; Neutrophils - metabolism; Paquinimod; S100A8/A9; SARS-CoV-2; SARS-CoV-2 - drug effects; Transcriptome; Viral Load; aberrant neutrophils; Paquinimod; S100A8/A9; SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses an unprecedented public health crisis. Evidence suggests that SARS-CoV-2 infection causes dysregulation of the immune system. However, the unique signature of early immune responses remains elusive. We characterized the...