Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

• Published in: The Journal of experimental medicine Vol. 214; no. 3; pp. 579 - 596
• Main Authors: Öhlund, Daniel, Handly-Santana, Abram, Biffi, Giulia, Elyada, Ela, Almeida, Ana S., Ponz-Sarvise, Mariano, Corbo, Vincenzo, Oni, Tobiloba E., Hearn, Stephen A., Lee, Eun Jung, Chio, Iok In Christine, Hwang, Chang-Il, Tiriac, Hervé, Baker, Lindsey A., Engle, Dannielle D., Feig, Christine, Kultti, Anne, Egeblad, Mikala, Fearon, Douglas T., Crawford, James M., Clevers, Hans, Park, Youngkyu, Tuveson, David A.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 06.03.2017; The Rockefeller University Press
• Subjects: Actin; Actins - analysis; Adenocarcinoma; Animals; Biology; Cancer; Carcinoma, Pancreatic Ductal - immunology; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Cell culture; Cells, Cultured; Crosstalk; Cytokines - biosynthesis; Etiology; Fibroblasts; Fibroblasts - physiology; Heterogeneity; Humans; Inflammation; Interleukin 6; Mice; Mice, Inbred C57BL; Muscles; Myofibroblasts - physiology; Organoids; Pancreatic cancer; Pancreatic Neoplasms - immunology; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Populations; Rodents; Smooth muscle; STAT3 Transcription Factor - metabolism; Stellate cells; Stromal cells

Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease progression and therapeutic response in pancreatic ductal adenocarcinoma (PDA). However, it is unknown whether CAFs uniformly carry out these tasks or...