Arabidopsis ABA response gene ABI1: features of a calcium-modulated protein phosphatase

• Published in: Science (American Association for the Advancement of Science) Vol. 264; no. 5164; pp. 1448 - 1452
• Main Authors: Leung, J, Bouvier-Durand, M, Morris, P.C, Guerrier, D, Chefdor, F, Giraudat, J
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 03.06.1994
• Subjects: Abscisic acid; Abscisic Acid - pharmacology; ACIDE ABSCISSIQUE; ACIDO ABSCISICO; Amino Acid Sequence; ARABIDOPSIS; Arabidopsis - chemistry; Arabidopsis - cytology; Arabidopsis - genetics; Arabidopsis - physiology; Arabidopsis Proteins; Calcium - metabolism; CLONE; CLONES; Cloning, Molecular; GENE; GENES; Genes, Plant; Genetic aspects; Mitosis; Molecular Sequence Data; Mutation; Phenotype; Phosphoprotein Phosphatases - chemistry; Phosphoprotein Phosphatases - genetics; Phosphoprotein Phosphatases - metabolism; Phosphorylation; Plant genetics; Plants, Genetically Modified; Polymorphism, Restriction Fragment Length; SECUENCIA NUCLEICA; SEQUENCE NUCLEIQUE; Signal Transduction; Space life sciences; Transformation, Genetic
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.7910981

The Arabidopsis ABI1 locus is essential for a wide spectrum of abscisic acid (ABA) responses throughout plant development. Here, ABI1 was shown to regulate stomatal aperture in leaves and mitotic activity in root meristems. The ABI1 gene was cloned and predicted to encode a signaling protein. Although its carboxyl-terminal domain is related to serine-threonine phosphatase 2C, the ABI1 protein has a unique amino-terminal extension containing an EF hand calcium-binding site. These results suggest that the ABI1 protein is a Ca2+-modulated phosphatase and functions to integrate ABA and Ca2+ signals with phosphorylation-dependent response pathways