Trophoblast damage with acute and chronic intervillositis: disruption of the placental barrier by severe acute respiratory syndrome coronavirus 2

• Published in: Human pathology Vol. 109; pp. 69 - 79
• Main Authors: Debelenko, Larisa, Katsyv, Igor, Chong, Alexander M., Peruyero, Leonore, Szabolcs, Matthias, Uhlemann, Anne-Catrin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2021; Elsevier Limited; Published by Elsevier Inc
• Subjects: Adult; Antibodies; Asymptomatic; Childbirth & labor; Cloning; Congenital diseases; Coronaviruses; COVID-19; COVID-19 - virology; Disease transmission; Female; Humans; Immunohistochemistry; In Situ Hybridization - methods; Infections; Microscopy; Original Contribution; Pathology; Placenta; Placenta - pathology; Placenta - virology; Pregnancy; qRT-PCR; RNA, Viral; SARS-CoV-2; SARS-CoV-2 - pathogenicity; Severe acute respiratory syndrome coronavirus 2; Trophoblasts - chemistry; Trophoblasts - pathology; Trophoblasts - virology; Vertical transmission; Viral Load; Iowa; Immunohistochemistry; Vertical transmission; SARS-CoV-2; Placenta; qRT-PCR

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was demonstrated in the placenta; however, the data on the prevalence of placental infection and associated histopathology are limited. To identify the frequency and features of SARS-CoV-2 involvement, we performed a clinicopathologic anal...