Antithrombotic Effect of shRNA Target F12 Mediated by Adeno-Associated Virus

• Published in: Molecular therapy. Nucleic acids Vol. 16; pp. 295 - 301
• Main Authors: Li, Fanfan, Yang, Xiao, Liu, Jie, Shu, Kuangyi, Shen, Chenfang, Chen, Tao, Yang, Wei, Li, Shanshan, Wang, Xiaoou, Jiang, Minghua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.06.2019; Elsevier Limited; American Society of Gene & Cell Therapy; Elsevier
• Subjects: Abdomen; Bleeding; Blood clots; Carotid arteries; Coagulation; Coagulation factor XII; Coagulation factors; Efficiency; Hemorrhage; Proteins; Ribonucleic acid; RNA; Side effects; Thrombosis; United States > US; China

Coagulation factor XII (FXII) plays a crucial role in thrombosis. Moreover, deficiencies in FXII are not associated with excessive bleeding, and its depletion exhibits satisfactory protective effect on thrombus formation. Several strategies targeting FXII have been applied to inhibit thrombosis form...