The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway

• Published in: Cell death and differentiation Vol. 24; no. 2; pp. 212 - 224
• Main Authors: Chen, Zhen-Hua, Wang, Wen-Tao, Huang, Wei, Fang, Ke, Sun, Yu-Meng, Liu, Shu-Rong, Luo, Xue-Qun, Chen, Yue-Qin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2017; Nature Publishing Group
• Subjects: 38; 42/109; 631/67/395; 692/699/1541; 96; 96/1; 96/106; 96/109; 96/95; Acids; Adolescent; Animals; Apoptosis; Argonaute Proteins - genetics; Argonaute Proteins - metabolism; Autophagy; Autophagy - drug effects; Autophagy-Related Protein-1 Homolog - antagonists & inhibitors; Autophagy-Related Protein-1 Homolog - genetics; Autophagy-Related Protein-1 Homolog - metabolism; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell cycle; Cell Cycle Analysis; Cell death; Cell Differentiation - drug effects; Cell Line, Tumor; Child; Child, Preschool; Down-Regulation - drug effects; E2F1 Transcription Factor - antagonists & inhibitors; E2F1 Transcription Factor - genetics; E2F1 Transcription Factor - metabolism; Female; Genes; HEK293 Cells; Humans; Infant; Infant, Newborn; Intracellular Signaling Peptides and Proteins - antagonists & inhibitors; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Laboratories; Leukemia; Leukemia, Promyelocytic, Acute - genetics; Leukemia, Promyelocytic, Acute - metabolism; Leukemia, Promyelocytic, Acute - pathology; Life Sciences; Male; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, SCID; MicroRNAs; MicroRNAs - antagonists & inhibitors; MicroRNAs - genetics; MicroRNAs - metabolism; Oncogene Proteins, Fusion - antagonists & inhibitors; Oncogene Proteins, Fusion - genetics; Oncogene Proteins, Fusion - metabolism; Original Paper; Proteolysis - drug effects; Stem Cells; Tretinoin - pharmacology; China

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great importance in different cell contexts. However, only a very small number of lncRNAs have been experimentally validated and functionally annotated during human hematopoiesis. Here, we report an lncRNA, HOTAIRM1, which i...