Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility - Senthilselvan, Ambikaipakan; Dosman, James A.; Chénard, Liliane; Burch, Lauranell H.; Predicala, Bernardo Z.; Sorowski, Randine; Schneberger, David; Hurst, Tom; Kirychuk, Shelley; Gerdts, Volker; Cormier, Yvon; Rennie, Donna C.; et al. (Journal of allergy and clinical immunology, 2009)
Keywords: Air Pollutants, Occupational - immunology; Airway hyperresponsiveness; Allergens - immunology; Allergy and Immunology; Animals; Asthma; Biological and medical sciences; Biomedical research; Blood; blood counts; Cytokines; Cytokines - blood; endotoxin; Endotoxins - immunology; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; gene-environment interaction; Housing, Animal; Humans; Hypersensitivity - immunology; Hypersensitivity - metabolism; Immunopathology; Indoor air quality; Inhalation Exposure; Leukocyte Count; Lung - immunology; Lung - metabolism; lung function; Male; Medical sciences; Polymorphism; Polymorphism, Genetic; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Studies; Sus scrofa; swine confinement facility; Toll-Like Receptor 4 - genetics; Toll-Like Receptor 4 - immunology; Toll-like receptor 4 variants; Young Adult; gene-environment interaction; blood counts; PC 20; Airway hyperresponsiveness; FVC; lung function; FEV 1; cytokines; swine confinement facility; Toll-like receptor 4 variants; TLR4; endotoxin; FEF 25-75; Forced expiratory volume in the first second; Forced vital capacity; Toll-like receptor 4; Methacholine dose required for a 20% decrease in FEV 1; Forced expiratory flow between 25% and 75% of forced vital capacity; Toll like receptor 4; Genetic variability; Hyperreactivity; Respiratory system; Endotoxin; Respiratory tract; Lung function; Immunology; Swine; Ungulata; Human; Immunopathology; Cytokine; Genotype; Variant; Toxin; Vertebrata; Mammalia; Genotype environment interaction; Artiodactyla; Blood cell count