Lens β-crystallins: The role of deamidation and related modifications in aging and cataract

• Published in: Progress in biophysics and molecular biology Vol. 115; no. 1; pp. 21 - 31
• Main Authors: Lampi, Kirsten J., Wilmarth, Phillip A., Murray, Matthew R., David, Larry L.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2014
• Subjects: Aging; Aging - metabolism; Amides - metabolism; Animals; Beta-crystallins; beta-Crystallins - chemistry; beta-Crystallins - metabolism; Cataract - metabolism; Cataracts; Deamidation; Humans; Lens, Crystalline - metabolism; Post-translational modification; Protein Stability; Proteomics; Cataracts; Post-translational modification; Aging; Deamidation; Beta-crystallins; Proteomics

Crystallins are the major proteins in the lens of the eye and function to maintain transparency of the lens. Of the human crystallins, α, β, and γ, the β-crystallins remain the most elusive in their structural significance due to their greater number of subunits and possible oligomer formations. The...