The structure of synthetic oligosaccharides in relation to factor IXa inhibition

• Published in: Thrombosis and haemostasis Vol. 88; no. 3; p. 432
• Main Authors: Hérault, J P, Gaich, C, Bono, F, Driguez, P A, Duchaussoy, P, Petitou, M, Herbert, J M
• Format: Journal Article
• Language: English
• Published: Germany 01.09.2002
• Subjects: Antithrombin III - pharmacology; Carbohydrate Sequence; Drug Design; Drug Interactions; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - pharmacology; Factor IXa - antagonists & inhibitors; Heparin - chemistry; Heparin - pharmacology; Humans; Oligosaccharides - chemistry; Oligosaccharides - pharmacology; Structure-Activity Relationship

We investigated the effect of various oligosaccharides (OS) on the inhibition of factor IXa by antithrombin (AT) in a purified system. The OS comprised the AT-binding pentasaccharide sequence prolonged by saccharide chains with various lengths and charges. We show that factor IXa inhibition depended...