Hepatocyte growth factor: molecular biomarker and player in cardioprotection and cardiovascular regeneration

• Published in: Thrombosis and haemostasis Vol. 107; no. 4; p. 656
• Main Authors: Madonna, R, Cevik, C, Nasser, M, De Caterina, R
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2012
• Subjects: Adult Stem Cells - cytology; Animals; Apoptosis; Biomarkers - metabolism; Cardiovascular Diseases - metabolism; Cardiovascular System - metabolism; Endothelial Cells - cytology; Gene Expression Regulation; Heart Failure; Hepatocyte Growth Factor - metabolism; Humans; Mice; Models, Biological; Myocardial Infarction - metabolism; Neovascularization, Physiologic; Rats

The liver possesses impressive regenerative capacities. Grafts of embryonic liver explants and liver explant-conditioned media have been shown to enhance the mitotic activity of hepatocytes. Hepatocyte growth factor (HGF), also named scatter factor (SF), has been identified as a primary candidate in...