Reducing Myocardial Infarction by Combination of Irisin and Dendrobium nobile Lindl through Inhibiting Nod-Like Receptor Protein-3-Related Pyroptosis and Activating PINK1/Parkin-Mitophagy during Aging

• Published in: Chinese journal of physiology Vol. 66; no. 5; pp. 351 - 358
• Main Authors: Ding, Chen, Zhang, Chaofeng
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow 01.09.2023; Medknow Publications and Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Edition: 2
• Subjects: Aging; Animals; Cytokines; Dendrobium - chemistry; dendrobium nobile lindl; Fibronectins; Heart attack; irisin; Male; Mitophagy; Myocardial Infarction - drug therapy; Myocardial Infarction - prevention & control; myocardial ischemia/reperfusion injury; NLR Family, Pyrin Domain-Containing 3 Protein; NLR Proteins; Original Article; Plant Preparations - pharmacology; Protein Kinases; Pyroptosis; Rats; Rats, Wistar; Reperfusion Injury - metabolism; Ubiquitin-Protein Ligases - metabolism; Aging; pyroptosis; Lindl; mitophagy; myocardial ischemia/reperfusion injury; irisin; Dendrobium nobile Lindl

Aging, a crucial risk factor for ischemic heart disease, has negative impacts on cardioprotective mechanisms. As such, there is still an unmet requirement to explore potential therapies for improving the outcomes of myocardial ischemia/reperfusion (IR) injury in elderly subjects. Here, we aimed to c...