Adaptation of adherent-invasive E. coli to gut environment: Impact on flagellum expression and bacterial colonization ability

• Published in: Gut microbes Vol. 11; no. 3; pp. 364 - 380
• Main Authors: Sevrin, Gwladys, Massier, Sébastien, Chassaing, Benoit, Agus, Allison, Delmas, Julien, Denizot, Jérémy, Billard, Elisabeth, Barnich, Nicolas
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 03.05.2020; Taylor & Francis Group
• Subjects: Animals; Bacterial Adhesion - genetics; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacteriology; Biochemistry, Molecular Biology; Caco-2 Cells; Colony Count, Microbial; Crohn Disease - microbiology; Escherichia coli - genetics; Escherichia coli - growth & development; Escherichia coli - pathogenicity; Escherichia coli - physiology; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Flagella - genetics; Flagella - metabolism; Flagellin - genetics; Flagellin - metabolism; Gene Expression Regulation, Bacterial; HT29 Cells; Humans; Intestinal Mucosa - microbiology; Intestines - chemistry; Intestines - microbiology; Life Sciences; Mice; Mice, Inbred C57BL; Microbiology and Parasitology; Molecular biology; Mucus - microbiology; Mutation; Phenotype; Research Paper

The pathogenesis of Crohn's disease (CD) is multifactorial and involves genetic susceptibility, environmental triggers and intestinal microbiota. Adherent-invasive Escherichia coli (AIEC) are flagellated bacteria more prevalent in CD patients than in healthy subjects and promote chronic intesti...