Probing vocal fold fibroblast response to hyaluronan in 3D contexts

• Published in: Biotechnology and bioengineering Vol. 104; no. 4; pp. 821 - 831
• Main Authors: Munoz-Pinto, Dany J., Jimenez-Vergara, Andrea Carolina, Gelves, L. Marcela, McMahon, Rebecca E., Guiza-Arguello, Viviana, Hahn, Mariah S.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2009; Wiley; Wiley Subscription Services, Inc
• Subjects: alginate; Animals; Biological and medical sciences; Biological Products - metabolism; Biotechnology; Carbohydrates; Cell culture; Cell Culture Techniques; Elastin - metabolism; Fibroblasts - drug effects; Fundamental and applied biological sciences. Psychology; hyaluronan; Hyaluronic Acid - metabolism; Hydrogels; Kinases; Mitogen-Activated Protein Kinase 3 - metabolism; PEG hydrogels; Protein Kinase C - metabolism; Studies; Swine; Transplants & implants; Vocal Cords - cytology; vocal fold; Ethylene oxide polymer; alginate; hyaluronan; PEG hydrogels; vocal fold; Alginates; Hydrogel; Fibroblast

A number of treatments are being investigated for vocal fold (VF) scar, including designer implants. The aim of the present study was to validate a 3D model system for probing the effects of various bioactive moieties on VF fibroblast (VFF) behavior toward rational implant design. We selected poly(e...