Quantification of Neural Ethanol and Acetaldehyde Using Headspace GC-MS

• Published in: Alcoholism, clinical and experimental research Vol. 40; no. 9; pp. 1825 - 1831
• Main Authors: Heit, Claire, Eriksson, Peter, Thompson, David C., Charkoftaki, Georgia, Fritz, Kristofer S., Vasiliou, Vasilis
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.09.2016
• Subjects: Acetaldehyde; Acetaldehyde - analysis; Alcoholism; Animals; Brain; Brain - drug effects; Brain Chemistry - drug effects; Brain Chemistry - physiology; Ethanol; Ethanol - administration & dosage; Ethanol - analysis; Female; Gas Chromatography-Mass Spectrometry - methods; Gas Chromatography-Mass Spectrometry - standards; GC-MS; Liver; Liver - chemistry; Liver - drug effects; Mice; Mice, Inbred C57BL; GC-MS; Brain; Ethanol; Liver; Acetaldehyde

Background There is controversy regarding the active agent responsible for alcohol addiction. The theory that ethanol (EtOH) itself was the agent in alcohol drinking behavior was widely accepted until acetaldehyde (AcH) was found in the brain. The importance of AcH formation in the brain is still su...