Highlighting new phylogenetic specificities of Crohn's disease microbiota

Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).MethodsFecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different meth...

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Published inInflammatory bowel diseases Vol. 17; no. 1; pp. 185 - 192
Main Authors Mondot, S., Kang, S., Furet, J. P., Aguirre de Carcer, D., McSweeney, C., Morrison, M., Marteau, P., Doré, J., Leclerc, M.
Format Journal Article
LanguageEnglish
Published Oxford, UK Oxford University Press 01.01.2011
Wiley Subscription Services, Inc., A Wiley Company
Lippincott, Williams & Wilkins
Subjects
16S rRNA
Adolescent
Adult
Aged
Aged, 80 and over
Agricultural sciences
Bifidobacterium bifidum
Bioinformatics
Case-Control Studies
Crohn Disease - diagnosis
Crohn Disease - genetics
Crohn Disease - microbiology
Crohn's disease
dysbiosis
Enterococcus faecium
Escherichia coli
Eubacterium rectale
Faecalibacterium prausnitzii
Feces
Female
Gastrointestinal tract
Gastrointestinal Tract - microbiology
Gastrointestinal Tract - pathology
Genetic testing
Humans
Inflammatory bowel diseases
Intestine
Life Sciences
Male
Metagenome - genetics
microarray
Microbiota
Middle Aged
Phylogenetics
Phylogeny
Polymerase chain reaction
Primers
Probes
Prognosis
Proteobacteria
Ruminococcus
Young Adult
microbiota
16S rRNA
microarray
Crohn's disease
dysbiosis
HOMEOSTASIS
FECAL MICROBIOTA
SMOKING
PREVALENCE
COMMENSALS
CLINICAL-COURSE
SOFTWARE
DIVERSITY
INFLAMMATORY BOWEL DISEASES
16S RIBOSOMAL-RNA
Online AccessGet full text

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Abstract Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).MethodsFecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria.ResultsEven though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected “healthy specific” molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level.ConclusionsThese two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool. (Inflamm Bowel Dis 2011;)
AbstractList BackgroundRecent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).MethodsFecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria.ResultsEven though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected “healthy specific” molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level.ConclusionsThese two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool. (Inflamm Bowel Dis 2011;)
Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).BACKGROUNDRecent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).Fecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria.METHODSFecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria.Even though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected "healthy specific" molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level.RESULTSEven though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected "healthy specific" molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level.These two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool.CONCLUSIONSThese two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool.
Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Fecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria. Even though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected "healthy specific" molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level. These two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool.
Background: Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Methods: Fecal samples were collected from 16 healthy individuals and 16 CD patients (age-and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria. Results: Even though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected "healthy specific'' molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level. Conclusions: These two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool.
Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).MethodsFecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria.ResultsEven though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected “healthy specific” molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level.ConclusionsThese two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool. (Inflamm Bowel Dis 2011;)
Background: Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Methods: Fecal samples were collected from 16 healthy individuals and 16 CD patients (age‐ and sex‐matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real‐time polymerase chain reaction (PCR) methods using primers designed using a high‐throughput in‐house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom‐designed phylogenetic microarray for intestinal bacteria. Results: Even though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected “healthy specific” molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level. Conclusions: These two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool. (Inflamm Bowel Dis 2011;)
Background: Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Methods: Fecal samples were collected from 16 healthy individuals and 16 CD patients (age- and sex-matched). The DNA extracted from these samples were subjected to two different methods of microbiome analysis. Specific bacterial groups were quantified by real-time polymerase chain reaction (PCR) methods using primers designed using a high-throughput in-house bioinformatics pipeline. The same DNA extracts were also used to produce fluorescently labeled cRNA amplicons to interrogate a custom-designed phylogenetic microarray for intestinal bacteria. Results: Even though the intersubject variability was high, differences in the fecal microbiomes of healthy and CD patients were detected. Faecalibacterium prausnitzii and Escherichia coli were more represented in healthy and ileal CD patients, respectively. Additionally, probes specific for Ruminococcus bromii, Oscillibacter valericigenes, Bifidobacterium bifidum, and Eubacterium rectale produced stronger hybridization signals with the DNA samples from healthy subjects. Conversely, species overrepresented in CD patients were E. coli, Enterococcus faecium, and species from the Proteobacteria not normally found in the healthy human GI tract. Furthermore, we detected 'healthy specific' molecular species or operational taxonomic units (OTUs) that are not closely related to any known species (Faecalibacterium, Subdoligranulum, and Oscillospora species), indicating that the phylogenetic dysbiosis is broader than at strain or species level. Conclusions: These two techniques of microbiome analysis provided a statistically robust new picture of the dysbiosis in fecal microbiota from ileal CD patients. Specifically, we identified a set of six species discriminant for CD, which provides a preliminary diagnostic tool. (Inflamm Bowel Dis 2011; )
Author Leclerc, M.
Aguirre de Carcer, D.
Marteau, P.
Kang, S.
McSweeney, C.
Mondot, S.
Doré, J.
Morrison, M.
Furet, J. P.
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  surname: Kang
  fullname: Kang, S.
  organization: 2CSIRO, St Lucia, Queensland, Australia
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  fullname: Furet, J. P.
  organization: 1UMR1319 MICALIS, INRA, Domaine de Vilvert, 78350 Jouy en Josas, France
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  surname: Aguirre de Carcer
  fullname: Aguirre de Carcer, D.
  organization: 2CSIRO, St Lucia, Queensland, Australia
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  organization: 2CSIRO, St Lucia, Queensland, Australia
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  fullname: Marteau, P.
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  organization: 1UMR1319 MICALIS, INRA, Domaine de Vilvert, 78350 Jouy en Josas, France
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  organization: 1UMR1319 MICALIS, INRA, Domaine de Vilvert, 78350 Jouy en Josas, France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/20722058$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/ng.175
10.1002/ibd.20828
10.1128/AEM.00474-06
10.1111/j.1462-2920.2008.01706.x
10.1111/j.1574-6941.2009.00671.x
10.1128/AEM.00556-06
10.1093/nar/gki198
10.1128/AEM.00325-08
10.1073/pnas.0804812105
10.1093/bioinformatics/bti394
10.1128/AEM.65.11.4799-4807.1999
10.1073/pnas.0706625104
10.1128/AEM.71.3.1501-1506.2005
10.1136/gut.2005.073817
10.1136/gut.2005.076604
10.1136/gut.53.1.1
10.1073/pnas.0808723105
10.1016/j.cell.2007.08.017
10.1053/j.gastro.2007.11.059
10.1111/j.1462-2920.2009.01982.x
10.1146/annurev.mi.31.100177.000543
10.1053/j.gastro.2004.04.061
10.1097/01.mib.0000235828.09305.0c
10.1128/JCM.41.7.2915-2923.2003
10.1053/j.gastro.2004.01.063
10.1016/j.mimet.2007.12.004
10.1136/gut.52.2.237
10.1126/science.1110591
10.1046/j.1365-2036.1999.00630.x
10.1136/gut.2006.118646
10.1038/nature07450
ContentType Journal Article
Copyright Copyright © 2010 Crohn's & Colitis Foundation of America, Inc. 2010
Copyright © 2010 Crohn's & Crohn's & Colitis Foundation of America, Inc.
Copyright © 2010 Crohn's & Colitis Foundation of America, Inc.
Distributed under a Creative Commons Attribution 4.0 International License
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Issue 1
Keywords microbiota
16S rRNA
microarray
Crohn's disease
dysbiosis
HOMEOSTASIS
FECAL MICROBIOTA
SMOKING
PREVALENCE
COMMENSALS
CLINICAL-COURSE
SOFTWARE
DIVERSITY
INFLAMMATORY BOWEL DISEASES
16S RIBOSOMAL-RNA
Language English
License Copyright © 2010 Crohn's & Crohn's & Colitis Foundation of America, Inc.
Distributed under a Creative Commons Attribution 4.0 International License: http://creativecommons.org/licenses/by/4.0
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PublicationTitle Inflammatory bowel diseases
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Lippincott, Williams & Wilkins
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References 2007; 104
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2004; 127
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2006; 12
2010
2006; 55
2004; 4
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2008; 74
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2004; 53
2007; 131
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2005; 308
2008; 456
2005; 71
2008; 134
2008; 40
2003; 41
2005; 33
2009; 15
Frank (R10-26-20140212) 2007; 104
Manichanh (R15-26-20140212) 2006; 55
Chessel (R28-26-20140212) 2004; 4
Culhane (R29-26-20140212) 2005; 21
Seksik (R3-26-20140212) 2009; 15
Bull (R11-26-20140212) 2003; 41
Furet (R26-26-20140212) 2009; 68
Salazar (R31-26-20140212) 2008; 74
DarfeuilleMichaud (R12-26-20140212) 2004; 127
Vaishnava (R7-26-20140212) 2008; 105
Savage (R9-26-20140212) 1977; 31
Sokol (R18-26-20140212) 2008; 105
Nuding (R33-26-20140212) 2007; 56
Garrett (R8-26-20140212) 2007; 131
Barrett (R1-26-20140212) 2008; 40
Fu (R24-26-20140212) 2008; 72
Eckburg (R14-26-20140212) 2005; 308
Schloss (R22-26-20140212) 2005; 71
Schloss (R23-26-20140212) 2006; 72
Seksik (R17-26-20140212) 2003; 52
Katoh (R20-26-20140212) 2005; 33
Sartor (R5-26-20140212) 2008; 134
MartinezMedina (R32-26-20140212) 2006; 12
Cosnes (R2-26-20140212) 1999; 13
Tamboli (R16-26-20140212) 2004; 53
Loy (R25-26-20140212) 2008; 10
Ashelford (R21-26-20140212) 2006; 72
Bouskra (R6-26-20140212) 2008; 456
Loftus (R4-26-20140212) 2004; 126
Tap (R30-26-20140212) 2009; 11
Suau (R13-26-20140212) 1999; 65
Marteau (R19-26-20140212) 2006; 55
References_xml – volume: 41
  start-page: 2915
  year: 2003
  end-page: 2923
  article-title: Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Crohn's disease
  publication-title: J Clin Microbiol
– volume: 134
  start-page: 577
  year: 2008
  end-page: 594
  article-title: Microbial influences in inflammatory bowel diseases
  publication-title: Gastroenterology
– volume: 104
  start-page: 13780
  year: 2007
  end-page: 13785
  article-title: Molecular‐phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
  publication-title: Proc Natl Acad Sci U S A
– volume: 65
  start-page: 4799
  year: 1999
  end-page: 4807
  article-title: Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut
  publication-title: Appl Environ Microbiol
– volume: 53
  start-page: 1
  year: 2004
  end-page: 4
  article-title: Dysbiosis in inflammatory bowel disease
  publication-title: Gut
– volume: 21
  start-page: 2789
  year: 2005
  end-page: 2790
  article-title: MADE4: an R package for multivariate analysis of gene expression data
  publication-title: Bioinformatics (Oxford)
– volume: 105
  start-page: 16731
  year: 2008
  end-page: 16736
  article-title: Faecalibacterium prausnitzii is an anti‐inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
  publication-title: Proc Natl Acad Sci U S A
– volume: 456
  start-page: 507
  year: 2008
  end-page: 510
  article-title: Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
  publication-title: Nature
– volume: 40
  start-page: 955
  year: 2008
  end-page: 962
  article-title: Genome‐wide association defines more than 30 distinct susceptibility loci for Crohn's disease
  publication-title: Nat Genet
– volume: 13
  start-page: 1403
  year: 1999
  end-page: 1411
  article-title: Effects of current and former cigarette smoking on the clinical course of Crohn's disease
  publication-title: Aliment Pharmacol Ther
– volume: 56
  start-page: 1240
  year: 2007
  end-page: 1247
  article-title: Reduced mucosal antimicrobial activity in Crohn's disease of the colon
  publication-title: Gut
– volume: 15
  start-page: 734
  year: 2009
  end-page: 741
  article-title: Effects of light smoking consumption on the clinical course of Crohn's disease
  publication-title: Inflamm Bowel Dis
– volume: 31
  start-page: 107
  year: 1977
  end-page: 133
  article-title: Microbial ecology of the gastrointestinal tract
  publication-title: Annu Rev Microbiol
– year: 2010
  article-title: Dysbiosis of faecal microbiota in Crohn's disease patients as revealed by a custom phylogenetic microarray
  publication-title: Inflamm Bowel Dis
– volume: 4
  start-page: 5
  year: 2004
  end-page: 10
  article-title: The ade4 package. I. One‐table methods
  publication-title: R News
– volume: 11
  start-page: 2574
  year: 2009
  end-page: 2584
  article-title: Towards the human intestinal microbiota phylogenetic core
  publication-title: Environ Microbiol
– volume: 52
  start-page: 237
  year: 2003
  end-page: 242
  article-title: Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon
  publication-title: Gut
– volume: 71
  start-page: 1501
  year: 2005
  end-page: 1506
  article-title: Introducing DOTUR, a computer program for defining operational taxonomic units and estimating species richness
  publication-title: Appl Environ Microbiol
– volume: 72
  start-page: 263
  year: 2008
  end-page: 267
  article-title: PRISE (PRImer SElector): software for designing sequence‐selective PCR primers
  publication-title: J Microbiol Methods
– volume: 74
  start-page: 4737
  year: 2008
  end-page: 4745
  article-title: Exopolysaccharides produced by intestinal Bifidobacterium strains act as fermentable substrates for human intestinal bacteria
  publication-title: Appl Environ Microbiol
– volume: 72
  start-page: 6773
  year: 2006
  end-page: 6779
  article-title: Introducing SONS, a tool for operational taxonomic unit‐based comparisons of microbial community memberships and structures
  publication-title: Appl Environ Microbiol
– volume: 105
  start-page: 20858
  year: 2008
  end-page: 20863
  article-title: Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host‐microbial interface
  publication-title: Proc Natl Acad Sci U S A
– volume: 131
  start-page: 33
  year: 2007
  end-page: 45
  article-title: Communicable ulcerative colitis induced by T‐bet deficiency in the innate immune system
  publication-title: Cell
– volume: 55
  start-page: 205
  year: 2006
  end-page: 211
  article-title: Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach
  publication-title: Gut
– volume: 308
  start-page: 1635
  year: 2005
  end-page: 1638
  article-title: Diversity of the human intestinal microbial flora
  publication-title: Science (New York)
– volume: 68
  start-page: 351
  year: 2009
  end-page: 362
  article-title: Comparative assessment of human and farm animal faecal microbiota using real‐time quantitative PCR
  publication-title: FEMS Microbiol Ecol
– volume: 10
  start-page: 2894
  year: 2008
  end-page: 2898
  article-title: probeCheck—a central resource for evaluating oligonucleotide probe coverage and specificity
  publication-title: Environ Microbiol
– volume: 126
  start-page: 1504
  year: 2004
  end-page: 1517
  article-title: Clinical epidemiology of inflammatory bowel disease: incidence, prevalence, and environmental influences
  publication-title: Gastroenterology
– volume: 55
  start-page: 842
  year: 2006
  end-page: 847
  article-title: Ineffectiveness of Lactobacillus johnsonii LA1 for prophylaxis of postoperative recurrence in Crohn's disease: a randomised, double blind, placebo controlled GETAID trial
  publication-title: Gut
– volume: 72
  start-page: 5734
  year: 2006
  end-page: 5741
  article-title: New screening software shows that most recent large 16S rRNA gene clone libraries contain chimeras
  publication-title: Appl Environ Microbiol
– volume: 33
  start-page: 511
  year: 2005
  end-page: 518
  article-title: MAFFT version 5: improvement in accuracy of multiple sequence alignment
  publication-title: Nucleic Acids Res
– volume: 12
  start-page: 1136
  year: 2006
  end-page: 1145
  article-title: Abnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction‐denaturing gradient gel electrophoresis
  publication-title: Inflamm Bowel Dis
– volume: 127
  start-page: 412
  year: 2004
  end-page: 421
  article-title: High prevalence of adherent‐invasive Escherichia coli associated with ileal mucosa in Crohn's disease
  publication-title: Gastroenterology
– volume: 40
  start-page: 955
  year: 2008
  ident: R1-26-20140212
  publication-title: Nat Genet
  doi: 10.1038/ng.175
– volume: 15
  start-page: 734
  year: 2009
  ident: R3-26-20140212
  publication-title: Inflamm Bowel Dis
  doi: 10.1002/ibd.20828
– volume: 72
  start-page: 6773
  year: 2006
  ident: R23-26-20140212
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00474-06
– volume: 10
  start-page: 2894
  year: 2008
  ident: R25-26-20140212
  publication-title: Environ Microbiol
  doi: 10.1111/j.1462-2920.2008.01706.x
– volume: 68
  start-page: 351
  year: 2009
  ident: R26-26-20140212
  publication-title: FEMS Microbiol Ecol
  doi: 10.1111/j.1574-6941.2009.00671.x
– volume: 72
  start-page: 5734
  year: 2006
  ident: R21-26-20140212
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00556-06
– volume: 33
  start-page: 511
  year: 2005
  ident: R20-26-20140212
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gki198
– volume: 74
  start-page: 4737
  year: 2008
  ident: R31-26-20140212
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00325-08
– volume: 105
  start-page: 16731
  year: 2008
  ident: R18-26-20140212
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0804812105
– volume: 21
  start-page: 2789
  year: 2005
  ident: R29-26-20140212
  publication-title: Bioinformatics (Oxford)
  doi: 10.1093/bioinformatics/bti394
– volume: 65
  start-page: 4799
  year: 1999
  ident: R13-26-20140212
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.65.11.4799-4807.1999
– volume: 104
  start-page: 13780
  year: 2007
  ident: R10-26-20140212
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0706625104
– volume: 71
  start-page: 1501
  year: 2005
  ident: R22-26-20140212
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.71.3.1501-1506.2005
– volume: 55
  start-page: 205
  year: 2006
  ident: R15-26-20140212
  publication-title: Gut
  doi: 10.1136/gut.2005.073817
– volume: 55
  start-page: 842
  year: 2006
  ident: R19-26-20140212
  publication-title: Gut
  doi: 10.1136/gut.2005.076604
– volume: 4
  start-page: 5
  year: 2004
  ident: R28-26-20140212
  publication-title: R News
– volume: 53
  start-page: 1
  year: 2004
  ident: R16-26-20140212
  publication-title: Gut
  doi: 10.1136/gut.53.1.1
– volume: 105
  start-page: 20858
  year: 2008
  ident: R7-26-20140212
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0808723105
– volume: 131
  start-page: 33
  year: 2007
  ident: R8-26-20140212
  publication-title: Cell
  doi: 10.1016/j.cell.2007.08.017
– volume: 134
  start-page: 577
  year: 2008
  ident: R5-26-20140212
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.11.059
– volume: 11
  start-page: 2574
  year: 2009
  ident: R30-26-20140212
  publication-title: Environ Microbiol
  doi: 10.1111/j.1462-2920.2009.01982.x
– volume: 31
  start-page: 107
  year: 1977
  ident: R9-26-20140212
  publication-title: Annu Rev Microbiol
  doi: 10.1146/annurev.mi.31.100177.000543
– volume: 127
  start-page: 412
  year: 2004
  ident: R12-26-20140212
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2004.04.061
– volume: 12
  start-page: 1136
  year: 2006
  ident: R32-26-20140212
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/01.mib.0000235828.09305.0c
– volume: 41
  start-page: 2915
  year: 2003
  ident: R11-26-20140212
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.41.7.2915-2923.2003
– volume: 126
  start-page: 1504
  year: 2004
  ident: R4-26-20140212
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2004.01.063
– volume: 72
  start-page: 263
  year: 2008
  ident: R24-26-20140212
  publication-title: J Microbiol Methods
  doi: 10.1016/j.mimet.2007.12.004
– volume: 52
  start-page: 237
  year: 2003
  ident: R17-26-20140212
  publication-title: Gut
  doi: 10.1136/gut.52.2.237
– volume: 308
  start-page: 1635
  year: 2005
  ident: R14-26-20140212
  publication-title: Science (New York)
  doi: 10.1126/science.1110591
– volume: 13
  start-page: 1403
  year: 1999
  ident: R2-26-20140212
  publication-title: Aliment Pharmacol Ther
  doi: 10.1046/j.1365-2036.1999.00630.x
– volume: 56
  start-page: 1240
  year: 2007
  ident: R33-26-20140212
  publication-title: Gut
  doi: 10.1136/gut.2006.118646
– volume: 456
  start-page: 507
  year: 2008
  ident: R6-26-20140212
  publication-title: Nature
  doi: 10.1038/nature07450
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Snippet Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).MethodsFecal samples were collected from 16...
Background: Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Methods: Fecal samples were...
Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Fecal samples were collected from 16...
BackgroundRecent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).MethodsFecal samples were...
Background: Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD). Methods: Fecal samples were...
Recent studies suggest that gastrointestinal (GI) microbes play a part in the pathogenesis of Crohn's disease (CD).BACKGROUNDRecent studies suggest that...
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SubjectTerms 16S rRNA
Adolescent
Adult
Aged
Aged, 80 and over
Agricultural sciences
Bifidobacterium bifidum
Bioinformatics
Case-Control Studies
Crohn Disease - diagnosis
Crohn Disease - genetics
Crohn Disease - microbiology
Crohn's disease
dysbiosis
Enterococcus faecium
Escherichia coli
Eubacterium rectale
Faecalibacterium prausnitzii
Feces
Female
Gastrointestinal tract
Gastrointestinal Tract - microbiology
Gastrointestinal Tract - pathology
Genetic testing
Humans
Inflammatory bowel diseases
Intestine
Life Sciences
Male
Metagenome - genetics
microarray
Microbiota
Middle Aged
Phylogenetics
Phylogeny
Polymerase chain reaction
Primers
Probes
Prognosis
Proteobacteria
Ruminococcus
Young Adult
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Title Highlighting new phylogenetic specificities of Crohn's disease microbiota
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