Long‐term intake of phenolic compounds attenuates age‐related cardiac remodeling

• Published in: Aging cell Vol. 18; no. 2; pp. e12894 - n/a
• Main Authors: Chacar, Stéphanie, Hajal, Joelle, Saliba, Youakim, Bois, Patrick, Louka, Nicolas, Maroun, Richard G., Faivre, Jean‐François, Fares, Nassim
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2019; Wiley Open Access; John Wiley and Sons Inc
• Subjects: Administration, Oral; Age; Aging; Analysis; Animals; Antioxidants; Apoptosis; Apoptosis - drug effects; Ca2+/calmodulin-dependent protein kinase II; Calcineurin; Calcium-binding protein; Calmodulin; cardiac remodeling; Cardiology and cardiovascular system; Cardiomyocytes; Diet; DNA damage; Dose-Response Relationship, Drug; Echocardiography; Enzymes; Extracellular matrix; Extracellular signal-regulated kinase; Fibrosis; Glycogen; Glycogen synthase kinase 3; Heart; Heart enlargement; Human health and pathology; Hypertrophy; Inflammation; Kinases; Life Sciences; Male; Models, Biological; NF-AT protein; Original; Oxidative Stress; Oxidative Stress - drug effects; Phenolic compounds; Phenols; Phenols - administration & dosage; Phenols - pharmacology; Preservation; Rats; Rats, Wistar; Reactive Oxygen Species; Reactive Oxygen Species - metabolism; Ribonucleic acid; RNA; Senescence; Smad protein; Synthesis; T cells; Transcription factors; Transforming growth factors; Ventricle; Ventricular Dysfunction, Left; Ventricular Dysfunction, Left - metabolism; Ventricular Dysfunction, Left - prevention & control; Ventricular Remodeling; Ventricular Remodeling - drug effects; phenolic compounds; fibrosis; aging; hypertrophy; oxidative stress; cardiac remodeling

With the onset of advanced age, cardiac‐associated pathologies have increased in prevalence. The hallmarks of cardiac aging include cardiomyocyte senescence, fibroblast proliferation, inflammation, and hypertrophy. The imbalance between levels of reactive oxygen species (ROS) and antioxidant enzymes...