Dietary glycated protein modulates the colonic microbiota towards a more detrimental composition in ulcerative colitis patients and non-ulcerative colitis subjects

• Published in: Journal of applied microbiology Vol. 105; no. 3; pp. 706 - 714
• Main Authors: Mills, D.J.S, Tuohy, K.M, Booth, J, Buck, M, Crabbe, M.J.C, Gibson, G.R, Ames, J.M
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01.09.2008; Blackwell Publishing Ltd; Blackwell Science
• Subjects: Adult; Aged; Analysis of Variance; Animals; Bacteria; Bacteria - drug effects; Bacteria - metabolism; Bacteriological Techniques; Bacteroides; Bacteroides - drug effects; Bacteroides - physiology; Bifidobacterium; Biological and medical sciences; bovine serum albumin; Case-Control Studies; Cattle; Clostridium; Clostridium - drug effects; Clostridium - physiology; colitis; Colitis, Ulcerative; Colitis, Ulcerative - microbiology; Colon; Colon - microbiology; colonic microbiota; Colony Count, Microbial; Colony Count, Microbial - methods; community structure; continuous flow culture; Dietary Proteins; Dietary Proteins - pharmacology; Digestion; drug effects; Eubacteria; Fatty Acids, Volatile; Fatty Acids, Volatile - metabolism; feces; Feces - microbiology; Female; Food; Fundamental and applied biological sciences. Psychology; glycated protein; Hot Temperature; Humans; In Situ Hybridization, Fluorescence; intestinal microorganisms; Male; metabolism; methods; Microbiology; Middle Aged; patients; pharmacology; physiology; Ribotyping; Serum Albumin; Serum Albumin - pharmacology; Serum Albumin, Bovine; Serum Albumin, Bovine - pharmacology; short chain fatty acids; sulfate-reducing bacteria; Sulfates; Sulfates - metabolism; ulcerative colitis; volunteers; Sulfate-reducing bacteria; Short chain; Applied microbiology; glycated protein; Patient; Microflora; Fatty acids; Protein; Continuous process; continuous flow culture; Diet; Chemical composition; Colon; colonic microbiota; short-chain fatty acids; Culture; Ulcerative colitis

To investigate the effect of native, heated and glycated bovine serum albumin (BSA) on the ulcerative colitis (UC) and non-UC colonic microbiota in vitro. Continuous flow culture (CFC) models of the human colonic microbiota inoculated with faeces from UC and non-UC volunteers were maintained on BSA...