Melanoidin, a Food Protein-Derived Advanced Maillard Reaction Product, Suppresses Helicobacter pylori in vitro and in vivo

• Published in: Helicobacter (Cambridge, Mass.) Vol. 9; no. 5; pp. 429 - 435
• Main Authors: Hiramoto, Shigeru, Itoh, Kazuro, Shizuuchi, Satomi, Kawachi, Yasuji, Morishita, Yoshirou, Nagase, Masao, Suzuki, Yoshio, Nobuta, Yukio, Sudou, Yuhshi, Nakamura, Osamu, Kagaya, Imae, Goshima, Hideo, Kodama, Yoshikatsu, Icatro, Faustino C., Koizumi, Wasaburo, Saigenji, Katsunori, Miura, Soichiro, Sugiyama, Toshiro, Kimura, Nobutake
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2004
• Subjects: Administration, Oral; Animals; Antigens, Bacterial - analysis; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Food; Gastric Mucins - metabolism; Gastric Mucosa - drug effects; Gastric Mucosa - microbiology; Helicobacter Infections - drug therapy; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - drug effects; Helicobacter pylori - immunology; Helicobacter pylori - isolation & purification; Humans; Maillard Reaction; Male; Mice; Mice, Nude; Polymers - pharmacology; Polymers - therapeutic use; Protein Binding - drug effects; Urease - metabolism

ABSTRACT Background.  Extracellular urease proteins located on the surface of Helicobacter pylori are gastric mucin‐targeted adhesins, which play an important role in infection and colonization to the host. In this study we have determined the inhibitory activity of a variety of melanoidins, protein...