The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus

• Published in: BMC research notes Vol. 13; no. 1; p. 502
• Main Authors: Prima, Heryu, Sofii, Imam, Fauzi, Aditya Rifqi, Dachlan, Ishandono, Gunadi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.10.2020; BioMed Central; BMC
• Subjects: Abdomen; Abdominal fascial closure; Abdominal Wound Closure Techniques; Angiogenesis; Animal bites; Animals; Collagen; Comparative analysis; Complications and side effects; Cytokines; Development and progression; Fascia; Fibroblasts; Health aspects; Hernia; Hernias; Incisional Hernia; Infections; Interleukin 6; Interleukin-6 - metabolism; Interleukin-6 expression; Laparotomy; Large stitch; Methods; Prevention; Quality of life; Rats; Research Note; Risk factors; Self image; Skin; Small stitch; Statistical analysis; Surgery; Suture Techniques; Sutures; Suturing; Wound healing; Indonesia; Abdominal fascial closure; Small stitch; Interleukin-6 expression; Incisional hernia; Large stitch
• ISSN: 1756-0500; 1756-0500
• DOI: 10.1186/s13104-020-05349-y

Incisional hernia is a frequent complication of midline laparotomy. The suturing technique is an important determinant of the risk of developing an incisional hernia. Moreover, IL-6 has crucial roles in the wound-healing process. We aimed to compare the large stitch vs. small stitch technique for abdominal fascial closure on IL-6 expressions in rats. Twenty rats were used. The small stitch group received small tissue bites of 5 mm and the large stitch group received large bites of 10 mm. The incisions of fascia were closed by running sutures. Animals were euthanized on days 4 and 7. Histological sections of the tissue-embedded sutures were analyzed for IL-6 expressions. Two-way ANOVA showed that rats in the small stitch group had similar IL-6 expressions on days 4 and 7 to those in the large stitch group (p = 0.36). In conclusion, the IL-6 expressions are similar between the small and the large stitch groups, implying that different suturing techniques might not have an impact on the incisional hernia occurrence.