The relative contribution of metabolic and structural abnormalities to diastolic dysfunction in obesity

• Published in: International Journal of Obesity Vol. 42; no. 3; pp. 441 - 447
• Main Authors: Rayner, J J, Banerjee, R, Holloway, C J, Lewis, A J M, Peterzan, M A, Francis, J M, Neubauer, S, Rider, O J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2018; Nature Publishing Group
• Subjects: 59/57; 692/499; 692/699/75; Abnormalities; Adult; Body mass; Body Mass Index; Cardiovascular diseases; Cohort Studies; Diastole (Cardiac cycle); Diastole - physiology; Epidemiology; Female; Health aspects; Health Promotion and Disease Prevention; Health risks; Heart diseases; Heart function; Humans; Hypertrophy; Internal Medicine; Intra-Abdominal Fat - diagnostic imaging; Intra-Abdominal Fat - physiopathology; Magnetic Resonance Imaging; Magnetic resonance spectroscopy; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Obesity; Obesity - diagnostic imaging; Obesity - epidemiology; Obesity - physiopathology; Original; original-article; Physiological aspects; Public Health; Risk analysis; Risk factors; Steatosis; Strain rate; Triglycerides; Triglycerides - blood; Ventricle; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology

Background: Obesity causes diastolic dysfunction, and is one of the leading causes of heart failure with preserved ejection fraction. Myocardial relaxation is determined by both active metabolic processes such as impaired energetic status and steatosis, as well as intrinsic myocardial remodelling. H...