Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study

[Display omitted] The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to report robotic-assisted in situ 3D bio-printing technology for cartilage regeneration, and explore its potential in clin...

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Published inJournal of advanced research Vol. 23; no. C; pp. 123 - 132
Main Authors Ma, Kaiwei, Zhao, Tianzheng, Yang, Longfei, Wang, Peng, Jin, Jing, Teng, Huajian, Xia, Dan, Zhu, Liya, Li, Lan, Jiang, Qing, Wang, Xingsong
Format Journal Article
LanguageEnglish
Published Egypt Elsevier B.V 01.05.2020
Elsevier
Subjects
Bio-ink crosslinking
Cartilage regeneration
In situ 3D bio-printing
Robot
Tissue engineering
Cartilage regeneration
In situ 3D bio-printing
Bio-ink crosslinking
Tissue engineering
Robot
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Abstract [Display omitted] The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to report robotic-assisted in situ 3D bio-printing technology for cartilage regeneration, and explore its potential in clinical application. A six-degree-of-freedom (6-DOF) robot was introduced in this study, and a fast tool center point (TCP) calibration method was developed to improve printing accuracy. The bio-ink consisted of hyaluronic acid methacrylate and acrylate-terminated 4-armed polyethylene glycol was employed as well. The in vitro experiment was performed on a resin model to verify the printing accuracy. The in vivo experiment was conducted on rabbits to evaluate the cartilage treatment capability. According to our results, the accuracy of the robot could be notably improved, and the error of printed surface was less than 30 μm. The osteochondral defect could be repaired during about 60 s, and the regenerated cartilage in hydrogel implantation and in situ 3D bio-printing groups demonstrated the same biomechanical and biochemical performance. We found that the cartilage injury could be treated by using this method. The robotic-assisted in situ 3D bio-printing is highly appropriate for improving surgical procedure, as well as promoting cartilage regeneration.
AbstractList The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to report robotic-assisted in situ 3D bio-printing technology for cartilage regeneration, and explore its potential in clinical application. A six-degree-of-freedom (6-DOF) robot was introduced in this study, and a fast tool center point (TCP) calibration method was developed to improve printing accuracy. The bio-ink consisted of hyaluronic acid methacrylate and acrylate-terminated 4-armed polyethylene glycol was employed as well. The in vitro experiment was performed on a resin model to verify the printing accuracy. The in vivo experiment was conducted on rabbits to evaluate the cartilage treatment capability. According to our results, the accuracy of the robot could be notably improved, and the error of printed surface was less than 30 μm. The osteochondral defect could be repaired during about 60 s, and the regenerated cartilage in hydrogel implantation and in situ 3D bio-printing groups demonstrated the same biomechanical and biochemical performance. We found that the cartilage injury could be treated by using this method. The robotic-assisted in situ 3D bio-printing is highly appropriate for improving surgical procedure, as well as promoting cartilage regeneration. Keywords: In situ 3D bio-printing, Cartilage regeneration, Tissue engineering, Bio-ink crosslinking, Robot
[Display omitted] The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to report robotic-assisted in situ 3D bio-printing technology for cartilage regeneration, and explore its potential in clinical application. A six-degree-of-freedom (6-DOF) robot was introduced in this study, and a fast tool center point (TCP) calibration method was developed to improve printing accuracy. The bio-ink consisted of hyaluronic acid methacrylate and acrylate-terminated 4-armed polyethylene glycol was employed as well. The in vitro experiment was performed on a resin model to verify the printing accuracy. The in vivo experiment was conducted on rabbits to evaluate the cartilage treatment capability. According to our results, the accuracy of the robot could be notably improved, and the error of printed surface was less than 30 μm. The osteochondral defect could be repaired during about 60 s, and the regenerated cartilage in hydrogel implantation and in situ 3D bio-printing groups demonstrated the same biomechanical and biochemical performance. We found that the cartilage injury could be treated by using this method. The robotic-assisted in situ 3D bio-printing is highly appropriate for improving surgical procedure, as well as promoting cartilage regeneration.
The concept of 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to report robotic-assisted 3D bio-printing technology for cartilage regeneration, and explore its potential in clinical application. A six-degree-of-freedom (6-DOF) robot was introduced in this study, and a fast tool center point (TCP) calibration method was developed to improve printing accuracy. The bio-ink consisted of hyaluronic acid methacrylate and acrylate-terminated 4-armed polyethylene glycol was employed as well. The experiment was performed on a resin model to verify the printing accuracy. The experiment was conducted on rabbits to evaluate the cartilage treatment capability. According to our results, the accuracy of the robot could be notably improved, and the error of printed surface was less than 30 μm. The osteochondral defect could be repaired during about 60 s, and the regenerated cartilage in hydrogel implantation and 3D bio-printing groups demonstrated the same biomechanical and biochemical performance. We found that the cartilage injury could be treated by using this method. The robotic-assisted 3D bio-printing is highly appropriate for improving surgical procedure, as well as promoting cartilage regeneration.
The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to report robotic-assisted in situ 3D bio-printing technology for cartilage regeneration, and explore its potential in clinical application. A six-degree-of-freedom (6-DOF) robot was introduced in this study, and a fast tool center point (TCP) calibration method was developed to improve printing accuracy. The bio-ink consisted of hyaluronic acid methacrylate and acrylate-terminated 4-armed polyethylene glycol was employed as well. The in vitro experiment was performed on a resin model to verify the printing accuracy. The in vivo experiment was conducted on rabbits to evaluate the cartilage treatment capability. According to our results, the accuracy of the robot could be notably improved, and the error of printed surface was less than 30 μm. The osteochondral defect could be repaired during about 60 s, and the regenerated cartilage in hydrogel implantation and in situ 3D bio-printing groups demonstrated the same biomechanical and biochemical performance. We found that the cartilage injury could be treated by using this method. The robotic-assisted in situ 3D bio-printing is highly appropriate for improving surgical procedure, as well as promoting cartilage regeneration.
Author Zhao, Tianzheng
Yang, Longfei
Wang, Peng
Wang, Xingsong
Ma, Kaiwei
Jin, Jing
Xia, Dan
Li, Lan
Jiang, Qing
Teng, Huajian
Zhu, Liya
AuthorAffiliation a School of Mechanical Engineering, Southeast University, Nanjing, China
b State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, China
c School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, China
AuthorAffiliation_xml – name: c School of Electrical and Automation Engineering, Nanjing Normal University, Nanjing, China
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32099674$$D View this record in MEDLINE/PubMed
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Issue C
Keywords Cartilage regeneration
In situ 3D bio-printing
Bio-ink crosslinking
Tissue engineering
Robot
Language English
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2020 THE AUTHORS. Published by Elsevier BV on behalf of Cairo University.
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SSID ssj0000388911
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Snippet [Display omitted] The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The...
The concept of 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed to...
The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed...
The concept of in situ 3D bio-printing was previously reported, while its realization has still encountered with several difficulties. The present study aimed...
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osti
proquest
crossref
pubmed
elsevier
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 123
SubjectTerms Bio-ink crosslinking
Cartilage regeneration
In situ 3D bio-printing
Robot
Tissue engineering
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Title Application of robotic-assisted in situ 3D printing in cartilage regeneration with HAMA hydrogel: An in vivo study
URI https://dx.doi.org/10.1016/j.jare.2020.01.010
https://www.ncbi.nlm.nih.gov/pubmed/32099674
https://search.proquest.com/docview/2365225846
https://www.osti.gov/biblio/1600051
https://pubmed.ncbi.nlm.nih.gov/PMC7030996
https://doaj.org/article/5f40c18b954b495e8414cdaa40dbcdd8
Volume 23
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