Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography

• Published in: Biological psychiatry (1969) Vol. 74; no. 10; pp. 768 - 776
• Main Authors: Hannestad, Jonas O., Cosgrove, Kelly P., DellaGioia, Nicole F., Perkins, Evgenia, Bois, Frederic, Bhagwagar, Zubin, Seibyl, John P., McClure-Begley, Tristan D., Picciotto, Marina R., Esterlis, Irina
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2013
• Subjects: Acetylcholine; Adult; Azetidines - administration & dosage; bipolar disorder; Bipolar Disorder - metabolism; Brain Chemistry; depression; Female; Humans; Male; Psychiatry; Pyridines - administration & dosage; Receptors, Nicotinic - analysis; Smoking; SPECT; tobacco smoking; Tomography, Emission-Computed, Single-Photon; β2-nAChR; bipolar disorder; tobacco smoking; Acetylcholine; β2-nAChR; depression; SPECT; β 2-nAChR; β-nAChR

The cholinergic system is substantially altered in individuals with major depression and is partially restored when depression remits. We quantified the availability of β2-subunit-containing nicotinic acetylcholine receptors (β2*-nAChR) in subjects with bipolar disorder. Twenty-five subjects with bi...