Modeling human zymogen factor IX

• Published in: Thrombosis and haemostasis Vol. 85; no. 4; p. 596
• Main Authors: Perera, L, Darden, T A, Pedersen, L G
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2001
• Subjects: Amino Acid Substitution; Calcium - chemistry; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Databases, Factual; Enzyme Activation; Factor IX - chemistry; Factor IX - genetics; Factor IX - metabolism; Factor IXa - biosynthesis; Factor IXa - chemistry; Humans; Models, Molecular; Motion; Mutation; Mutation, Missense; Protein Conformation; Protein Structure, Tertiary; Serine Endopeptidases - chemistry; Static Electricity; Structure-Activity Relationship

Modern theoretical techniques are employed to provide complete three dimensional structure for the zymogen and activated forms of human coagulation factors IX and IXa. These structures are fully calcium bound and equilibrated in an electrically neutral aqueous environment. The relationship of struct...