Critical Appraisal of DNA Microarrays in Psychiatric Genomics

• Published in: Biological psychiatry (1969) Vol. 60; no. 2; pp. 163 - 176
• Main Authors: Mirnics, Károly, Levitt, Pat, Lewis, David A.
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.07.2006; Elsevier Science
• Subjects: Adult and adolescent clinical studies; Biological and medical sciences; DNA - genetics; DNA microarray; gene expression; Gene Expression Regulation - genetics; Gene Expression Regulation - physiology; Genomics - instrumentation; human brain; Humans; Medical sciences; Mental Disorders - genetics; Miscellaneous; Oligonucleotide Array Sequence Analysis; psychiatric disorders; Psychiatry - instrumentation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; transcriptome; DNA microarray; human brain; transcriptome; gene expression; psychiatric disorders; Human; Central nervous system; DNA chip; Mental disorder; Gene expression; Encephalon

Transcriptome profiling using DNA microarrays are data-driven approaches with the potential to uncover unanticipated relationships between gene expression alterations and psychiatric disorders. Studies to date have yielded both convergent and divergent findings. Differences may be explained, at leas...