Detection of complement-fixing antiphospholipid antibodies in association with thrombosis

• Published in: Thrombosis and haemostasis Vol. 83; no. 5; p. 728
• Main Authors: Munakata, Y, Saito, T, Matsuda, K, Seino, J, Shibata, S, Sasaki, T
• Format: Journal Article
• Language: English
• Published: Germany 01.05.2000
• Subjects: Antibodies, Antiphospholipid - blood; Antiphospholipid Syndrome - blood; Antiphospholipid Syndrome - complications; Antiphospholipid Syndrome - immunology; Autoimmune Diseases - blood; Autoimmune Diseases - complications; Autoimmune Diseases - immunology; Cerebral Infarction - blood; Cerebral Infarction - etiology; Cerebral Infarction - immunology; Complement Fixation Tests; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G - blood; Immunoglobulin G - classification; Immunoglobulin G - immunology; Lupus Erythematosus, Systemic - blood; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - immunology; Myocardial Infarction - blood; Myocardial Infarction - etiology; Myocardial Infarction - immunology; Rheumatic Diseases - blood; Rheumatic Diseases - complications; Rheumatic Diseases - immunology; Thrombophilia - blood; Thrombophilia - complications; Thrombophilia - immunology

Antiphospholipid antibody (aPL) is a hallmark of antiphospholipid syndrome (APS), characterized by thrombosis and recurrent fetal loss. We developed a novel ELISA system to detect complement-fixing ability of anticardiolipin antibody (aCL), and evaluated its clinical usefulness through studying the...