Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

• Published in: Nature (London) Vol. 479; no. 7374; pp. 547 - 551
• Main Authors: Kang, Tae-Won, Yevsa, Tetyana, Woller, Norman, Hoenicke, Lisa, Wuestefeld, Torsten, Dauch, Daniel, Hohmeyer, Anja, Gereke, Marcus, Rudalska, Ramona, Potapova, Anna, Iken, Marcus, Vucur, Mihael, Weiss, Siegfried, Heikenwalder, Mathias, Khan, Sadaf, Gil, Jesus, Bruder, Dunja, Manns, Michael, Schirmacher, Peter, Tacke, Frank, Ott, Michael, Luedde, Tom, Longerich, Thomas, Kubicka, Stefan, Zender, Lars
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.11.2011; Nature Publishing Group
• Subjects: 631/67/580/1884; 631/80/509; 692/308; 692/699/67/1504/1610; Abnormalities; Aging; Animal tumors. Experimental tumors; Animals; Antigens, Neoplasm - immunology; Biological and medical sciences; Cancer; Cancer Vaccines - immunology; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - prevention & control; CD4-Positive T-Lymphocytes - immunology; Cellular Senescence - genetics; Cellular Senescence - immunology; Disease Progression; Experimental digestive system and abdominal tumors; Genes, ras - genetics; Growth factors; Health aspects; Hepatocytes - cytology; Hepatocytes - immunology; Hepatocytes - metabolism; Hepatocytes - pathology; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunologic Surveillance - immunology; letter; Liver - cytology; Liver - immunology; Liver cancer; Liver cells; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Liver Neoplasms - prevention & control; Lymphocytes; Medical sciences; Mice; Mice, SCID; multidisciplinary; Phagocytosis; Precancerous Conditions - genetics; Precancerous Conditions - immunology; Precancerous Conditions - pathology; Precancerous Conditions - prevention & control; Science; Science (multidisciplinary); Tumors; Germany; Senescence; Premalignant lesion; Immune response; Rodentia; Hepatic disease; Malignant tumor; Carcinogenesis; Liver cancer; Immunological surveillance; Vertebrata; Mammalia; Cancerology; Hepatocyte; Mouse; Animal; Digestive diseases; Cancer

Senescence surveillance in cancer Oncogene-induced senescence has been shown to function as an intrinsic tumour suppressor mechanism. Lars Zender and colleagues now introduce the concept of 'senescence surveillance' by showing that premaligant senescent hepatocytes are cleared through a tu...