Biochemical and pharmacological effects of the direct thrombin inhibitor AR-H067637

• Published in: Thrombosis and haemostasis Vol. 101; no. 6; p. 1051
• Main Authors: Deinum, Johanna, Mattsson, Christer, Inghardt, Tord, Elg, Margareta
• Format: Journal Article
• Language: English
• Published: Germany 01.06.2009
• Subjects: Amidines - pharmacokinetics; Amidines - pharmacology; Anticoagulants - pharmacology; Azetidines - pharmacokinetics; Azetidines - pharmacology; Binding, Competitive; Blood Coagulation - drug effects; Blood Coagulation Factors - metabolism; Blood Platelets - enzymology; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Inhibitory Concentration 50; Male; Platelet Activation - drug effects; Protein Binding; Thrombin - antagonists & inhibitors; Whole Blood Coagulation Time

AZD0837 is in development as a new oral anticoagulant for use in thromboembolic disorders. In vivo, AZD0837 is converted to AR-H067637, a selective and reversible direct thrombin inhibitor. Established biochemical methods were used to assess and measure the biochemical and pharmacological properties...