Effect of the Melanocortin 4-Receptor Ile269Asn Mutation on Weight Loss Response to Dietary, Phentermine and Bariatric Surgery Interventions

• Published in: Genes Vol. 13; no. 12; p. 2267
• Main Authors: Salazar-Valencia, Itzel G, Villamil-Ramírez, Hugo, Barajas-Olmos, Francisco, Guevara-Cruz, Martha, Macias-Kauffer, Luis R, García-Ortiz, Humberto, Hernández-Vergara, Omar, Díaz de Sandy-Galán, David Alberto, León-Mimila, Paola, Centeno-Cruz, Federico, González-Salazar, Luis E, Guizar-Heredia, Rocío, Pichardo-Ontiveros, Edgar, Jacobo-Albavera, Leonor, Posadas-Sánchez, Rosalinda, Vargas-Alarcón, Gilberto, Velazquez-Cruz, Rafael, Gutiérrez-Aguilar, Ruth, Zerrweck, Carlos, Rocha-González, Héctor Isaac, Reyes-García, Juan Gerardo, Carrasco-Portugal, Miriam Del C, Flores-Murrieta, Francisco Javier, Tovar, Armando R, Orozco, Lorena, Villarreal-Molina, Teresa, Canizales-Quinteros, Samuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2022; MDPI
• Subjects: Adult; Age; Alleles; Bariatric Surgery; Body weight loss; Carbohydrates; Cell receptors; Dietary restrictions; Drug therapy; Exercise; Gastric bypass; Gastrointestinal surgery; Genetic aspects; Glucose; Health aspects; Hispanic Americans; Humans; Ile269Asn-mutation; Insulin resistance; Intervention; interventions; Melanocortin; Melanocortin MC4 receptors; melanocortin-4-receptor; Mutation; Mutation (Biology); Obesity; Obesity - genetics; Obesity - surgery; Patients; Phentermine; Physical fitness; Receptor, Melanocortin, Type 4 - genetics; Surgery; Weight control; Weight Loss - genetics; weight-loss; Mexico; United States > US; Ile269Asn-mutation; weight-loss; interventions; obesity; melanocortin-4-receptor

The loss of function melanocortin 4-receptor ( ) Ile269Asn mutation has been proposed as one of the most important genetic contributors to obesity in the Mexican population. However, whether patients bearing this mutation respond differently to weight loss treatments is unknown. We tested the associ...