Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation

• Published in: Mucosal immunology Vol. 13; no. 4; pp. 626 - 636
• Main Authors: Kabata, Hiroki, Flamar, Anne-Laure, Mahlakõiv, Tanel, Moriyama, Saya, Rodewald, Hans-Reimer, Ziegler, Steven F., Artis, David
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.07.2020; Nature Publishing Group US; Elsevier Limited
• Subjects: Adaptive Immunity; Allergology; Animals; Antibodies; Asthma; Atopic dermatitis; Biomarkers; Biomedical and Life Sciences; Biomedicine; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Cell lineage; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Disease Models, Animal; Disease Susceptibility; Gastroenterology; Gene deletion; Gene Knockdown Techniques; Gene Targeting; Helper cells; Immunity, Innate; Immunoglobulins - genetics; Immunohistochemistry; Immunology; Inflammation; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Leukocytes (basophilic); Lymphocytes T; Lymphoid cells; Mice; Mice, Knockout; Papain; Receptors, Cytokine - genetics; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Respiratory tract; Respiratory tract diseases; Thymic stromal lymphopoietin; Thymus

Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis. Accumulating evidence suggests that TSLP can directly stimulate a variety of immune cells, such as dendritic cells (DCs), basophils, T cells,...