Nephron formation adopts a novel spatial topology at cessation of nephrogenesis

• Published in: Developmental biology Vol. 360; no. 1; pp. 110 - 122
• Main Authors: Rumballe, Bree A., Georgas, Kylie M., Combes, Alexander N., Ju, Adler L., Gilbert, Thierry, Little, Melissa H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2011
• Subjects: 3D modeling; Animals; Animals, Newborn; Cap mesenchyme; complement; Confocal microscopy; Cyclin D1 - genetics; Cyclin D1 - metabolism; embryogenesis; Female; Gene expression; Gene Expression Regulation, Developmental; genes; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; Imaging, Three-Dimensional; Kidney - embryology; Kidney - growth & development; Kidney - physiology; Kidney development; Mice; Models, Anatomic; Models, Biological; Morphogenesis; Nephrogenesis; Nephron induction; nephrons; Nephrons - embryology; Nephrons - growth & development; Nephrons - physiology; Optical Projection Tomography; Organogenesis - genetics; Organogenesis - physiology; Pregnancy; protein synthesis; renal function; tomography; Tomography, Optical; topology; Transcription Factors - genetics; Transcription Factors - metabolism; Ureter - embryology; Ureter - growth & development; Ureteric tip; Morphogenesis; 3D modeling; Ureteric tip; Optical Projection Tomography; Nephrogenesis; Nephron induction; Confocal microscopy; Cap mesenchyme; Gene expression; Kidney development

Nephron number in the mammalian kidney is known to vary dramatically, with postnatal renal function directly influenced by nephron complement. What determines final nephron number is poorly understood but nephron formation in the mouse kidney ceases within the first few days after birth, presumably...