Targeting Mast Cells in Allergic Disease: Current Therapies and Drug Repurposing

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 19; p. 3031
• Main Authors: Burchett, Jason R, Dailey, Jordan M, Kee, Sydney A, Pryor, Destiny T, Kotha, Aditya, Kankaria, Roma A, Straus, David B, Ryan, John J
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.09.2022; MDPI
• Subjects: Allergic reaction; Allergies; Allergy; Anaphylaxis; Asthma; atopy; Autoimmunity; Binding sites; Cell activation; Clinical trials; Cytokines; Dermatitis; Disease; Drug dosages; Drug Repositioning; Drug targeting; Drug therapy; FDA approval; Gene expression; Health aspects; Histamine; Humans; Hypersensitivity; IgE; Immunoglobulin E; Immunoglobulin E - metabolism; Inflammation; Interleukin 13; Interleukin 4; Interleukin-13 - metabolism; Interleukin-4 - metabolism; mast cell; Mast cells; Mast Cells - metabolism; Medical research; Metabolic disorders; Methods; Monoclonal antibodies; repurposing; Review; Urticaria; United States; United States > US; STAT; statin; JAK; inflammation; IgE; atopy; mast cell; repositioning; allergy; repurposing

The incidence of allergic disease has grown tremendously in the past three generations. While current treatments are effective for some, there is considerable unmet need. Mast cells are critical effectors of allergic inflammation. Their secreted mediators and the receptors for these mediators have l...